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Introduction: In children with diabetes mellitus type I (DM1) increased risk of autoimmune diseases, including multiglandular disorders, is observed. Aim of the study: To assess the prevalence of autoimmune diseases in children with DM1 in South-Eastern Poland was the aim of the study. Material and methods: 654 children with DM1 hospitalized in Pediatric Department of The State Hospital in Rzeszów during 10 consecutive years between January 1999 and December 2008 were enrolled into the study. Serologic tests for celiac disease (CD) as well as TSH and thyroid hormones concentration measurements were performed at least once in all patients. Other diagnostic procedures were ordered according to clinical indications. Results: Coexistence of DM1 and other autoimmune diseases was found in 47 children (7.2%). Hashimoto thyroiditis (n=20) and CD (n=18) occurred most frequently. Juvenile idiopathic arthritis and Graves-Basedow disease were diagnosed in 3 and 2 children respectively. In single cases DM1 coexisted with: autoimmune hepatitis, Addison disease, autoimmune hemolytic anemia, anky-losing spondylitis, Behcet disease, hypogonadotropic hypogonadism, psoriasis, systemic lupus erythematosus, vitiligo, alopecia areata. In 6 cases coexistence of more than 2 autoimmune diseases was found. Conclusions: Thyroid diseases and CD are the most frequently occurring autoimmune diseases in children with DM1 in our region. Frequency of their occurrence justifies screening tests in all children with DM1. [ABSTRACT FROM AUTHOR]

Autoimmune thyroiditis (AIT) is characterised by infiltration of lymphocytes and destruction of thyroid gland. It results from the interaction of genetic predisposition and environmental triggers. Among environmental factors some infections, medications and inadequate micronutrients supply like selenium (Se) deficiency are believed to play a role., Aim: The aim of our study was to assess the serum selenium concentration in patients with AIT and healthy volunteers in the Polish population living in the Poznan district, and to compare our results with similar trials conducted on other European AIT groups., Materials and Methods: Fifty three patients with AIT were included in the study. Elevated thyroperoxidase antibodies and/or thyroglobulin antibodies concentration and abnormalities typical for AIT in the thyroid ultrasound were the inclusion criteria. A control group consisted of 36 healthy, age and sex-matched volunteers., Results: The median Se concentration was 56.67 μg/L in the AIT group and 39.75 μg/L in the controls (p>0.05). Decreased Se concentration was observed in 62% of the patients and in 72% of the controls (p=0.47). There was no statistically significant difference in Se status in AIT group when compared to the other Polish, German, Austrian, Dutch and Greek populations with AIT. Significantly higher values were observed in Italian and Greek study when compared to present results in AIT group., Conclusions: No association between selenium status and prevalence of autoimmune thyroiditis in Polish population living in Poznan district was noticed. Nevertheless determination of the normal serum Se concentration for European populations is necessary. Further studies with enlarged studied groups should be implemented., (© 2018 MEDPRESS.)