1. Validation of 'ItchApp©' in Poland and in the USA: multicentre validation study of an electronical diary for the assessment of pruritus.
- Author
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Schnitzler, C., Rosen, J., Szepietowski, J.C., Reich, A., Yosipovitch, G., Reszke, R., Nattkemper, L.A., Osada, N., Pihan, D., Ständer, S., and Zeidler, C.
- Subjects
TAX assessment - Abstract
Background: Although chronic pruritus affects a large part of the population, its reliable assessment remains difficult. Electronical diaries (eDiaries) are often used in multicentre clinical trials. The ItchApp© for Android was developed to assess itch intensity and course and was validated for the German language in 2017. Objective: To validate ItchApp© for the use in the Polish and US English languages. Methods: Fifty‐three subjects in Poland and thirty subjects in the USA with chronic pruritus completed the paper‐based and app‐based questionnaires. These questionnaires contained items for measuring the itch intensity, including a numerical rating scale (NRS) and verbal rating scale (VRS), and for detecting the change of pruritus since the beginning of treatment. Results: The ItchApp© showed a high level of test–retest reliability [Intraclass correlation, Kappa and Kendall‐Tau B coefficients: 0.915–1.000 (Poland) and 0.863–1.000 (USA)]. The convergent validity showed strong correlation between the itch intensity scales on the ItchApp© (Items II‐IV = VRS mean, NRS mean and NRS worst) and the paper‐based itch intensity scales (mean and worst: VRS, NRS, VAS) [Spearman‐Rho and Pearson correlation coefficients: 0.710–0.987 (Poland) and 0.646–0.954 (USA)]. The ItchApp© items moderately correlated with the ItchyQol scores [Spearman‐Rho and Pearson correlation coefficients: 0.303–0.554 (Poland) and 0.275–0.447 (USA)]. After completing the ItchApp© questionnaire, a feasibility questionnaire was completed and showed that subjects feel the app is well suited for assessing pruritus. Conclusion: We provide evidence for the ItchApp© as a validated eDiary for the assessment of pruritus in Polish and US English languages, enabling its use in multicentre international clinical trials. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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