1. Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013-2016.
- Author
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Subissi, Lorenzo, Dub, Timothée, Besnard, Marianne, Mariteragi-Helle, Teheipuaura, Tuxuan Nhan, Lutringer-Magnin, Delphine, Barboza, Philippe, Gurry, Céline, Brindel, Pauline, Nilles, Eric J., Baud, David, Merianos, Angela, Musso, Didier, Glynn, Judith R., Dupuis, Gilles, Van-Mai Cao-Lormeau, Giard, Marine, Mallet, Henri-Pierre, Nhan, Tuxuan, and Cao-Lormeau, Van-Mai
- Subjects
INFANTS ,ZIKA Virus Epidemic, 2015-2016 ,PREGNANCY ,ZIKA virus infections ,MICROCEPHALY ,COMMUNICABLE disease diagnosis ,COMMUNICABLE disease epidemiology ,HUMAN abnormalities ,CHILD development ,COMMUNICABLE diseases ,COMPARATIVE studies ,HISTORY ,RESEARCH methodology ,MEDICAL cooperation ,HEALTH outcome assessment ,PREGNANCY complications ,PUBLIC health surveillance ,RESEARCH ,EVALUATION research ,CROSS-sectional method ,CASE-control method ,PRENATAL exposure delayed effects ,ODDS ratio ,MATERNAL exposure - Abstract
Congenital Zika virus syndrome consists of a large spectrum of neurologic abnormalities seen in infants infected with Zika virus in utero. However, little is known about the effects of Zika virus intrauterine infection on the neurocognitive development of children born without birth defects. Using a case-control study design, we investigated the temporal association of a cluster of congenital defects with Zika virus infection. In a nested study, we also assessed the early childhood development of children recruited in the initial study as controls who were born without known birth defects,. We found evidence for an association of congenital defects with both maternal Zika virus seropositivity (time of infection unknown) and symptomatic Zika virus infection during pregnancy. Although the early childhood development assessment found no excess burden of developmental delay associated with maternal Zika virus infection, larger, longer-term studies are needed. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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