1. Validation of the Portuguese version of the Movement Disorder Society non-motor rating scale (MDS-NMS) in Parkinson's disease.
- Author
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Vale TC, Santos DP, Oliveira DS, Paula Brandão PR, Pereira DA, Bouça-Machado R, Silva LO, Mello Rieder CR, Barbosa ER, Cury RG, Parmera JB, Ghizoni Teive HA, Ferreira MG, Ferraz HB, Candeias da Silva C, Tumas V, Nunes Cunha AL, Braga-Neto P, Lima DP, Della Colleta MV, Maia D, de Souza Fontana M, Damas CN, Lobo PP, Rebordão L, Magalhães AD, Peralta AR, Simões RM, Lampreia T, Velon AG, Carneiro D, Raimundo R, Gago M, Mendes A, Chã NV, Damásio J, Costa S, Lopes R, Morgadinho A, Mestre T, Stebbins GT, Luo S, Goetz CG, Ferreira JJ, and Cardoso F
- Subjects
- Humans, Male, Female, Aged, Middle Aged, Cross-Sectional Studies, Portugal, Reproducibility of Results, Brazil, Severity of Illness Index, Translations, Translating, Factor Analysis, Statistical, Parkinson Disease complications, Parkinson Disease diagnosis, Psychometrics standards
- Abstract
Background: The Movement Disorder Society Non-Motor Rating Scale (MDS-NMS) serves as a comprehensive clinical assessment tool for non-motor symptoms in Parkinson's disease (PD) OBJECTIVES: This study aims to validate the Portuguese version of the MDS-NMS, addressing the critical need for culturally adapted rating scales in Portuguese-speaking populations., Methods: This multicenter, cross-sectional study engaged native Portuguese-speaking PD patients from 16 Movement Disorders Centers across Portugal and Brazil. We conducted a meticulous translation process into Portuguese, including forward-backward translation and cognitive pretesting. Confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) were conducted to evaluate the psychometric properties and structural validity of the Portuguese version in comparison to the original English version. Tertiary analyses assessed the acceptability and reliability of domain scores within the cohort., Results: The scale was administered to 386 PD Portuguese-speaking patients. CFA, conducted with a final sample of 303 participants, confirmed that the Portuguese version maintained a factor structure consistent with the English original, with Comparative Fit Index (CFI) values meeting or exceeding the 0.90 threshold across all subscales. High CFI values in domains such as Depression, Psychosis, and Cognition underscored the robustness of the translation. EFA revealed generally strong item-factor relationships, although domains like Gastrointestinal and Non-Motor Fluctuations exhibited more complex structures. Reliability analyses demonstrated strong internal consistency, with Cronbach's α ranging from 0.50 to 0.86 across domains, further corroborated by McDonald's ω and Greatest Lower Bound values., Conclusions: The Portuguese version of the MDS-NMS demonstrates psychometric properties and structural validity that closely aligns with the original version., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Thiago Cardoso Vale reports financial support was provided by International Parkinson and Movement Disorder Society. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 Elsevier Ltd. All rights reserved.)
- Published
- 2025
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