1. Long-term prognosis of women with Brugada syndrome and electrophysiological study.
- Author
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Rodríguez-Mañero M, Jordá P, Hernandez J, Muñoz C, Grima EZ, García-Fernández A, Cañadas-Godoy MV, Jiménez-Ramos V, Oloriz T, Basterra N, Calvo D, Pérez-Álvarez L, Arias MA, Expósito V, Alemán A, Díaz-Infante E, Guerra-Ramos JM, Fernández-Armenta J, Arce-Leon Á, Sanchez-Gómez JM, Sousa P, García-Bolao I, Baluja A, Campuzano O, Sarquella-Brugada G, Martinez-Sande JL, González-Juanatey JR, Gimeno JR, Brugada J, and Arbelo E
- Subjects
- Adult, Brugada Syndrome complications, Brugada Syndrome physiopathology, Death, Sudden, Cardiac epidemiology, Female, Follow-Up Studies, Humans, Incidence, Male, Portugal epidemiology, Prognosis, Retrospective Studies, Risk Factors, Spain epidemiology, Survival Rate trends, Time Factors, Brugada Syndrome diagnosis, Death, Sudden, Cardiac etiology, Electrocardiography methods, Risk Assessment methods, Women's Health
- Abstract
Background: A male predominance in Brugada syndrome (BrS) has been widely reported, but scarce information on female patients with BrS is available., Objective: The purpose of this study was to investigate the clinical characteristics and long-term prognosis of women with BrS., Methods: A multicenter retrospective study of patients diagnosed with BrS and previous electrophysiological study (EPS) was performed., Results: Among 770 patients, 177 (23%) were female. At presentation, 150 (84.7%) were asymptomatic. Females presented less frequently with a type 1 electrocardiographic pattern (30.5% vs 55.0%; P <.001), had a higher rate of family history of sudden cardiac death (49.7% vs 29.8%; P <.001), and had less sustained ventricular arrhythmias (VAs) on EPS (8.5% vs 15.1%; P = .009). Genetic testing was performed in 79 females (45% of the sample) and was positive in 34 (19%). An implantable cardioverter-defibrillator was inserted in 48 females (27.1%). During mean (± SD) follow-up of 122.17 ± 57.28 months, 5 females (2.8%) experienced a cardiovascular event compared to 42 males (7.1%; P = .04). On multivariable analysis, a positive genetic test (18.71; 95% confidence interval [CI] 1.82-192.53; P = .01) and atrial fibrillation (odds ratio 21.12; 95% CI 1.27-350.85; P = .03) were predictive of arrhythmic events, whereas VAs on EPS (neither with 1 or 2 extrastimuli nor 3 extrastimuli) were not., Conclusion: Women with BrS represent a minor fraction among patients with BrS, and although their rate of events is low, they do not constitute a risk-free group. Neither clinical risk factors nor EPS predicts future arrhythmic events. Only atrial fibrillation and positive genetic test were identified as risk factors for future arrhythmic events., (Copyright © 2021 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
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