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2 results on '"Naas, Thierry"'

1. Emergence of New Non-Clonal Group 258 High-Risk Clones among Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Isolates, France.

Author

Bonnin, Rémy A., Jousset, Agnès B., Chiarelli, Adriana, Emeraud, Cécile, Glaser, Philippe, Naas, Thierry, and Dortet, Laurent

Subjects
KLEBSIELLA pneumoniae, WESTERN countries, DRUG resistance in microorganisms, SEQUENCE analysis, KLEBSIELLA, BACTERIAL proteins, RESEARCH, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, KLEBSIELLA infections, HYDROLASES, COMPARATIVE studies, CELLS, ANTIBIOTICS, PHARMACODYNAMICS
Abstract

The worldwide spread of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) isolates was reported to be caused by dissemination of 1 clonal complex (i.e., clonal group [CG] 258, which includes sequence types [STs] 258 and 512). We conducted whole-genome sequencing and epidemiologic analysis of all KPC-Kp isolates in France in 2018 and found that new successful high-risk clones of ST147, ST307, ST231, and ST383 are now the main drivers of blaKPC genes. The blaKPC genes were mostly carried by Tn4401a and Tn4401d structures and a new non-Tn4401 element. Our epidemiologic investigations showed that the emergence of these non-CG258 KPC-Kp isolates in France was linked to dissemination of these clones from Portugal. Thus, KPC-Kp epidemiology has changed in Europe, at least in several non-KPC-endemic countries of western Europe, such as France and Portugal, where CG258 is not the most prevalent clone. [ABSTRACT FROM AUTHOR]

Published
2020
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2. MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment.

Author

Beyrouthy R, Robin F, Lessene A, Lacombat I, Dortet L, Naas T, Ponties V, and Bonnet R

Subjects
Adult, Bacterial Proteins metabolism, Carbapenem-Resistant Enterobacteriaceae genetics, Escherichia coli Infections drug therapy, Escherichia coli Infections microbiology, France, Genome, Bacterial genetics, Humans, Klebsiella Infections drug therapy, Klebsiella Infections microbiology, Klebsiella pneumoniae drug effects, Klebsiella pneumoniae genetics, Male, Plasmids genetics, Portugal, beta-Lactamases metabolism, Anti-Bacterial Agents therapeutic use, Bacterial Proteins genetics, Colistin therapeutic use, Drug Resistance, Multiple, Bacterial genetics, Escherichia coli drug effects, Escherichia coli genetics, Escherichia coli Proteins genetics, beta-Lactamases genetics
Abstract

The spread of mcr-1 -encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1 -encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France., (Copyright © 2017 American Society for Microbiology.)

Published
2017
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