1. Cytotoxicity of Hymenocallis expansa alkaloids.
- Author
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Antoun MD, Mendoza NT, Ríos YR, Proctor GR, Wickramaratne DB, Pezzuto JM, and Kinghorn AD
- Subjects
- Alkaloids isolation & purification, Animals, Antineoplastic Agents, Phytogenic isolation & purification, Cell Line, Humans, Mice, Puerto Rico, Tumor Cells, Cultured drug effects, Alkaloids pharmacology, Amaryllidaceae Alkaloids, Antineoplastic Agents, Phytogenic pharmacology, Phenanthridines, Plants, Medicinal chemistry
- Abstract
From the bulbs and leaves of Hymenocallis expansa (Amaryllidaceae), three alkaloid constituents were identified: (+)-tazettine, (+)-hippeastrine, and (-)-haemanthidine. These alkaloids demonstrated significant cytotoxicity when tested against a panel of human and murine tumor cell lines.
- Published
- 1993
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