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Introduction Obesity is a public health problem that has raised concern worldwide. Numerous epidemiological Studies have showed the relationship between excess weight, abdominal fatness and risk of a wide range of illnesses (i.e. diabetes), People who are obese experience health-related quality-of-life impairments. The purpose of this study was to demonstrate the Comparison of Living Quality obese with normal weight women in Qazvin. Materials and Methods A case-control study was performed on women of Qazvin who were obese and normal-weight. Total of 115 women with obesity and 114 controls (with normal-weight) were randomly selected. Obesity was determined based on BMI and SF-36 questionnaire using for quality of life. Data were analyzed using soft ware of SPSS and 95% confidence Interval. Results The results showed that obese women were significantly more impaired than normal weight women in six of eight Domains: domains such as physical Functioning (p<0.001), physical Role limitation (p=0.01), bodily pain (p=0.05), general health perception (p=0.012), vitality (p=0.014), and social Functioning (p=0.045). Conclusion Women with obesity had experienced poor levels of health, particularly poor levels of physical and social well-being. [ABSTRACT FROM AUTHOR]