1. Transmission Clustering Drives the Onward Spread of the HIV Epidemic Among Men Who Have Sex With Men in Quebec.
- Author
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Brenner, Bluma G., Roger, Michel, Stephens, David, Moisi, Daniela, Hardy, Isabelle, Weinberg, Jonathan, Turgel, Reuven, Charest, Hugues, Koopman, James, and Wainberg, Mark A.
- Subjects
HIV infections ,MEN who have sex with men ,COMMUNICABLE diseases ,EPIDEMIOLOGY ,SOCIAL networks ,EPIDEMICS - Abstract
Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001-2009): 420 unique PHIs, 102 small clusters (2-4 PHIs per cluster, n = 280), and 46 large clusters (5-31 PHIs per cluster, n 5 450). Large clusters disproportionately increased from 25.2%of PHIs in 2005 to 39.1%in 2009 (x
2 = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5-25.5 months) correlated with cluster membership size (r2 = 0.174, F = 4.424, P = .047). PHI cohort data revealed variations in social networks and risk behaviors among the 3 groups, suggesting the need for tailored prevention measures. [ABSTRACT FROM AUTHOR]- Published
- 2011
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