1. Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking.
- Author
-
Ryu B, Cho HM, Zhang M, Lee BW, Doan TP, Park EJ, Lee HJ, and Oh WK
- Subjects
- China, Molecular Docking Simulation, Plant Leaves, Republic of Korea, Tandem Mass Spectrometry, Vietnam, Psidium
- Abstract
MS/MS-based molecular networking showed differences in the chemical profiles, especially the terpenoid-coupled-phloroglucinol clusters, of Psidium guajava grown in Jeju Island of South Korea ("Jejuguava"), Vietnam and China. A chemical investigation of the 95% EtOH extract of Jejuguava leaves revealed meroterpenoids characterized by a dihydropyran ring junction between an acylphloroglucinol structure and terpenoid, and named jejuguajavones A-J (1-10). Compounds (±)-8-(±)-10 are racemic mixtures that were separated using a chiral HPLC column. The chemical structures of all the isolated compounds (1-10) were determined by analyzing the spectroscopic data and performing electronic circular dichroism calculations. Among the isolates, compounds 1-4 exhibit inhibitory activity against the protein tyrosine phosphatase 1B (PTP1B) enzyme, and this result was confirmed by molecular docking simulations., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
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