1. A new cytotoxic coumarin, 7-[(E)-3',7'-dimethyl-6'-oxo-2',7'-octadienyl] oxy coumarin, from the leaves of Zanthoxylum schinifolium.
- Author
-
Min BK, Hyun DG, Jeong SY, Kim YH, Ma ES, and Woo MH
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Cell Survival drug effects, Chromatography, High Pressure Liquid, Coumarins chemistry, Coumarins isolation & purification, Humans, Inhibitory Concentration 50, Isomerism, Jurkat Cells, Leukemia, T-Cell drug therapy, Magnetic Resonance Spectroscopy, Mass Spectrometry, Methylene Chloride chemistry, Molecular Structure, Plant Extracts chemistry, Plant Extracts isolation & purification, Plant Extracts pharmacology, Republic of Korea, Solvents chemistry, Spectroscopy, Fourier Transform Infrared, Antineoplastic Agents, Phytogenic pharmacology, Coumarins pharmacology, Drug Discovery, Plant Leaves chemistry, Zanthoxylum chemistry
- Abstract
A new coumarin, 7-[(E)-3',7'-dimethyl-6'-oxo-2',7'-octadienyl]oxy coumarin (1), together with three known compounds, schinilenol (2), schinindiol (3) and 7-[(E)-7'-hydroxy-3',7'-dimethylocta-2',5'-dienyloxy]-coumarin (4) were isolated from the methylene chloride fraction of Z. schinifolium by normal and reverse phase column chromatographies. Their structures were determined on the basis of physical and spectroscopic evidences. Compound 1 (IC(50) 8.10 μM) showed potent cytotoxicity compared to auraptene (IC(50) 55.36 μM) against Jurkat T cells. The other isolated compounds 2 and 4 exhibited weak cytotoxicities.
- Published
- 2011
- Full Text
- View/download PDF