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Background: Deficits in sleep are associated with metabolic derangements, but the effect of sleep supplementation on metabolic derangements remains to be elucidated. This study aimed to investigate whether weekend catch-up sleep is associated with metabolic derangements in Korean adults., Methods: A total of 10,749 individuals over 40 years old were identified from the 2016-2017 Korea National Health and Nutrition Examination Survey. Data on demographics, health behaviors, self-reported sleep duration, and physician-diagnosed metabolic diseases were used in this analysis. The odds ratio for each metabolic derangement was determined via stepwise multivariable logistic regression models., Results: Short weekday sleep and insufficient weekend catch-up sleep were independently associated with an increased risk for all metabolic derangements, except hypertension. Individuals who did not make up sleep on the weekend were more likely to be obese and have type 2 diabetes or hypercholesterolemia.