1. Inflammation‐based modified Glasgow prognostic score and renal outcome in chronic kidney disease patients: is there a relationship?
- Author
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Stefan, Gabriel, Stancu, Simona, Zugravu, Adrian, and Capusa, Cristina
- Subjects
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CHRONIC kidney failure , *DISEASE progression , *ALBUMINS , *C-reactive protein , *GLOMERULAR filtration rate , *STATISTICS , *KRUSKAL-Wallis Test , *BIOMARKERS , *CONFIDENCE intervals , *INFLAMMATION , *MULTIVARIATE analysis , *LOG-rank test , *RETROSPECTIVE studies , *ACQUISITION of data , *RISK assessment , *DESCRIPTIVE statistics , *SURVIVAL analysis (Biometry) , *KAPLAN-Meier estimator , *MEDICAL records , *STATISTICAL models , *DATA analysis software , *LONGITUDINAL method , *ALBUMINURIA , *PROPORTIONAL hazards models , *DISEASE risk factors - Abstract
Background: Chronic kidney disease (CKD) progression is presumably related to inflammatory response. The modified Glasgow prognostic score (mGPS), based on a combination of albumin and C‐reactive protein, has been derived from oncology and validated in multiple diseases. Aims: To evaluate the relationship between the mGPS and CKD progression. Methods: The present retrospective unicentric cohort study included 547 CKD patients (age 60.2 years; 53% male; estimated glomerular filtration (eGFR) 42.0 mL/min; mean change −2 mL/min/year) admitted between 1 January 2007 and 31 December 2012. Patients' records were reviewed from the CKD diagnosis to one of the four outcomes: end‐stage kidney disease (ESKD), death, loss to follow up or until 31 July 2017. Results: The mGPS score was 0 for 420 (78%), 1 for 110 (19%) and 2 for 17 (3%) patients. More patients with rapid CKD progression were found in the group with the highest mGPS (P = 0.05). mGPS was negatively correlated with baseline eGFR and positively with albuminuria. In the multivariate analysis, mGPS was associated with the eGFR slope. During the study period, 130 (24%) patients died and 109 (20%) reached ESKD. The mean kidney survival time was 8.1 (95% confidence interval 7.9–8.4) years. Patients with zero mGPS had better kidney survival than those with the score of 1 and 2 (Kaplan–Meier, P = 0.02). However, the kidney survival differences were not present after adjusting for CKD progression risk factors. Conclusion: The inflammation‐based mGPS score was associated with eGFR decline in CKD patients. Therefore, could prove useful in improving risk stratification of CKD patients. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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