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Researchers from the University of Rome have conducted a study on medulloblastoma, a lethal pediatric brain tumor. The study focused on the Sonic Hedgehog (SHH) molecular subgroup of medulloblastoma, which is characterized by alterations in the SHH development pathway. The researchers identified formins, which are involved in cytoskeletal dynamics, as regulators of SHH signaling and found that they can affect the growth and stiffness of SHH-dependent tumor cells. These findings provide insights into the role of the cytoskeleton in medulloblastoma and could potentially lead to the development of innovative interventions. [Extracted from the article]