1. Koschei the immortal and anti-aging drugs.
- Author
-
Blagosklonny MV
- Subjects
- Aging metabolism, Angiotensin-Converting Enzyme Inhibitors pharmacology, Aspirin pharmacology, Exercise, Folklore, Gene Expression, Glucose metabolism, Humans, Insulin Resistance, Longevity physiology, Metformin pharmacology, Propranolol pharmacology, Russia, TOR Serine-Threonine Kinases metabolism, Aging drug effects, Caloric Restriction, Longevity drug effects, Sirolimus pharmacology, TOR Serine-Threonine Kinases antagonists & inhibitors
- Abstract
In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors.
- Published
- 2014
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