1. [The role of matrix metalloproteinases in assessment of prognosis in patients with ST-elevation myocardial infarction during hospital stay].
- Author
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Pecherina TB, Gruzdeva OV, Kashtalap VV, and Barbarash OL
- Subjects
- Biomarkers blood, Cohort Studies, Electrocardiography, Female, Hospitalization, Humans, Male, Middle Aged, Outcome Assessment, Health Care, Prognosis, ROC Curve, Recurrence, Risk Assessment methods, Risk Factors, Russia epidemiology, Time Factors, Matrix Metalloproteinase 9 blood, Myocardial Infarction blood, Myocardial Infarction diagnosis, Myocardial Infarction epidemiology, Myocardial Infarction therapy
- Abstract
Aim of the study was to investigate role of matrix metalloproteinases (MMP) in assessment of prognosis of repetitive cardiovascular events during hospital stay of patients with ST-elevation (STE) myocardial infarction (MI). We consecutively included into this study 175 patients with diagnosis of STEMI. Content of MMP-1, MMP-3 and MMP-9 in blood serum was measured at admission and on day 12 after onset of disease. Levels of all MMPs on day 12 were 1.1-1.6 times higher than on day 1 of MI (<0.05). Comparison of groups of patients with favorable and unfavorable outcome showed that patients with unfavorable outcome had higher median concentrations of MMP-3 and MMP-9 on day 1; this tendency was maintained on day 12. However these differences were significant only for MMP-9. Compared with patients with favorable outcome levels of this marker in patients with unfavorable outcome were higher by 19.4% (=0.04) on day 1 and by 48.8% (=0.03) on day 12. At logistic regression analysis for MMP-9 and unfavorable outcomes during hospital stay area under ROC-curve did not exceed 0.5. But when only inhospital deaths were considered 2 for MMP-9 (day 1) was 14.3 (<0.0001) while area under ROC-curve was 0.72 (0.64; 0.78; =0.02). Thus in patients with STEMI high concentrations of MMP-9 on day 1 of STEMI can come forward as independent marker of unfavorable outcome during hospital stay.
- Published
- 2013