1. A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial.
- Author
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Hayden KM, Makeeva OA, Newby LK, Plassman BL, Markova VV, Dunham A, Romero HR, Melikyan ZA, Germain CM, Welsh-Bohmer KA, and Roses AD
- Subjects
- Aged, Aged, 80 and over, Alzheimer Disease complications, Cognition Disorders etiology, Female, Humans, Male, Middle Aged, Russia, Surveys and Questionnaires, Translations, United States, Cognition physiology, Cognition Disorders diagnosis, Cross-Cultural Comparison, Neuropsychological Tests
- Abstract
Background: Understanding regional differences in cognitive performance is important for interpretation of data from large multinational clinical trials., Methods: Data from Durham and Cabarrus Counties in North Carolina, USA and Tomsk, Russia (n = 2972) were evaluated. The Montreal Cognitive Assessment (MoCA), Trail Making Test Part B (Trails B), Consortium to Establish a Registry for Alzheimer's Disease Word List Memory Test (WLM) delayed recall, and self-report Alzheimer's Disease Cooperative Studies Mail-In Cognitive Function Screening Instrument (MCFSI) were administered at each site. Multilevel modeling measured the variance explained by site and predictors of cognitive performance., Results: Site differences accounted for 11% of the variation in the MoCA, 1.6% in Trails B, 1.7% in WLM, and 0.8% in MCFSI scores. Prior memory testing was significantly associated with WLM. Diabetes and stroke were significantly associated with Trails B and MCFSI., Conclusions: Sources of variation include cultural differences, health conditions, and exposure to test stimuli. Findings highlight the importance of local norms to interpret test performance., (Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
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