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The article examines the using of media rumors as pragmatic influence mechanism in the modern communication. The printed and electronic messages with rumors make the material of research. The complex methods of analysis of the rumors role in the modern society are used. The inductive, descriptive and comparative, cognitive and discursive, semantic, definitional, functional and stylistic analysis is carried out. For the complex analysis of rumors in the modern media discourse, verbal means of rumors impact on the addressee in modern foreign-language and Russian mass media linguacultural, linguapragmatic, discursive approaches are applied. In the article, we realize the aim of the study. We identify the role of media rumors in the modern society. The ways of analysis are useful for development of rumorology, communication theory, linguapragmatics, sociolinguistics, cultural linguistics, media linguistics. In the article, we establish that mass media trying to realize the function of estimation and critics create and spread rumors themselves, use actively pseudo arguments and lie instead of exposure of various rumors, pseudo arguments, lies.

The development of the transport and logistics system in the direction of Russian-Chinese cross-border cooperation is an important direction not only from the point of view of economic prospects, but also from the point of view of political cooperation. The article is devoted to the development and substantiation of proposals for deepening the integration processes of the transport and logistics market of Russia and China. The trends in the development of the world market of transport and logistics services are analyzed with an emphasis on the border regions of Russia and China; identified its key problems and possible directions for their solution to deepen the subsequent integration between the border regions; an assessment of the effectiveness of the development of the transport infrastructure of the border regions of Russia, as well as the prospects for integrating Russia into the system of world economic relations in the Asia-Pacific region (APR) is given. [ABSTRACT FROM AUTHOR]

This article discusses the main changes in the field of digital and cryptocurrencies, as well as their interpretation from the standpoint of the common theory of money (e.g. the definition of monetary functions). The consequences of the central banks' monetary policies as well as their reaction by launching their own digital currency (central bank digital currency/CBDC) have also been dwelt upon. The possible changes in the global currency system have been outlined. Special attention has been paid to the development of higher economic education as a result of the new monetary and financial technologies and the digital economy. These topics have been set forth against the background of the experience of different countries (with a particular emphasis on Russia's practice), as well as by summarizing leading research and publications in the field. [ABSTRACT FROM AUTHOR]

This manuscript collects all the efforts of the Russian Consortium, bottlenecks revealed in the course of the C-HPP realization, and ways of their overcoming. One of the main bottlenecks in the C-HPP is the insufficient sensitivity of proteomic technologies, hampering the detection of low- and ultralow-copy number proteins forming the "dark part" of the human proteome. In the frame of MP-Challenge, to increase proteome coverage we suggest an experimental workflow based on a combination of shotgun technology and selected reaction monitoring with two-dimensional alkaline fractionation. Further, to detect proteins that cannot be identified by such technologies, nanotechnologies such as combined atomic force microscopy with molecular fishing and/or nanowire detection may be useful. These technologies provide a powerful tool for single molecule analysis, by analogy with nanopore sequencing during genome analysis. To systematically analyze the functional features of some proteins (CP50 Challenge), we created a mathematical model that predicts the number of proteins differing in amino acid sequence: proteoforms. According to our data, we should expect about 100 000 different proteoforms in the liver tissue and a little more in the HepG2 cell line. The variety of proteins forming the whole human proteome significantly exceeds these results due to post-translational modifications (PTMs). As PTMs determine the functional specificity of the protein, we propose using a combination of gene-centric transcriptome-proteomic analysis with preliminary fractionation by two-dimensional electrophoresis to identify chemically modified proteoforms. Despite the complexity of the proposed solutions, such integrative approaches could be fruitful for MP50 and CP50 Challenges in the framework of the C-HPP.

During the 2010 Human Proteome Organization Congress in Sydney, a gene-centric approach emerged as a feasible and tractable scaffold for assemblage of the Human Proteome Project. Bringing the gene-centric principle into practice, a roadmap for the 18th chromosome was drafted, postulating the limited sensitivity of analytical methods, as a serious bottleneck in proteomics. In the context of the sensitivity problem, we refer to the "copy number of protein molecules" as a measurable assessment of protein abundance. The roadmap is focused on the development of technology to attain the low- and ultralow -"copied" portion of the proteome. Roadmap merges the genomic, transcriptomic and proteomic levels to identify the majority of 285 proteins from 18th chromosome - master proteins. Master protein is the primary translation of the coding sequence and resembling at least one of the known isoforms, coded by the gene. The executive phase of the roadmap includes the expansion of the study of the master proteins with alternate splicing, single amino acid polymorphisms (SAPs) and post-translational modifications. In implementing the roadmap, Russian scientists are expecting to establish proteomic technologies for integrating MS and atomic force microscopy (AFM). These technologies are anticipated to unlock the value of new biomarkers at a detection limit of 10(-18) M, i.e. 1 protein copy per 1 μL of plasma. The roadmap plan is posted at www.proteome.ru/en/roadmap/ and a forum for discussion of the document is supported., (Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)