1. A trial in the Karelian Republic of oral rehydration and Lactobacillus GG for treatment of acute diarrhoea.
- Author
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Shornikova AV, Isolauri E, Burkanova L, Lukovnikova S, and Vesikari T
- Subjects
- Acute Disease, Age Distribution, Child, Preschool, Diarrhea, Infantile microbiology, Double-Blind Method, Humans, Infant, Osmolar Concentration, Rehydration Solutions chemistry, Russia, Seasons, Time Factors, Diarrhea, Infantile therapy, Fluid Therapy methods, Lactobacillus
- Abstract
In a controlled trial in Petrozavodsk, Karelia, the effects of oral rehydration and Lactobacillus strain GG (LGG) on recovery from acute diarrhoea (27% rotavirus, 21% bacterial aetiology) were studied in 123 children aged between 1 and 36 months of age. On admission to hospital, the patients were first randomized to receive either isotonic oral rehydration solution (ORS) with osmolarity 311 mosmol/l and sodium 90 mmol/l (WHO-ORS), or a hypotonic ORS with osmolarity 224 mosmol/l and sodium 60 mmol/l (Light-ORS), and thereafter randomized to receive either 5 x 10(9) colony forming units of LGG or a matching placebo. The two ORS performed equally for acute rehydration, and oral rehydration with either ORS was associated with a shorter duration of diarrhoea than intravenous rehydration (p = 0.036). Patients receiving LGG had a significantly shorter duration of watery diarrhoea [mean (SD) 2.7 (2.2) days] than those receiving the placebo [3.7 (2.8) days, p = 0.03]. LGG significantly shortened the duration of rotavirus diarrhoea but not diarrhoea with confirmed bacterial aetiology.
- Published
- 1997
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