1. New sesterterpene sulfates from the sponge Darwinella australensis.
- Author
-
Makarieva TN, Rho JR, Lee HS, Santalova EA, Stonik V, and Shin J
- Subjects
- Animals, Cell Division drug effects, Eggs, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Russia, Sea Urchins drug effects, Sesterterpenes, Structure-Activity Relationship, Sulfuric Acid Esters chemistry, Sulfuric Acid Esters pharmacology, Terpenes chemistry, Terpenes pharmacology, Porifera chemistry, Sulfuric Acid Esters isolation & purification, Terpenes isolation & purification
- Abstract
Three new sesterterpene sulfates, halisulfates 8-10 (1-3), were isolated from the Australian sponge Darwinella australensis. The structures of these compounds were determined by combined spectroscopic methods. The stereochemistry of the decalin moiety was assigned on the basis of NMR interpretations. Halisulfates 9 and 10 inhibited cell division of sea urchin eggs in moderate concentration.
- Published
- 2003
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