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Mesoporous Santa Barbara amorphous (SBA-15) was functionalized through co‐condensation using tetraethoxy orthosilicate and 3-aminopropyltriethoxysilane in the presence of the copolymer Pluronic P-123 (EO20PO70EO20) as a pore‐directing agent under an acidic condition. A comprehensive study of the sodium valproate (SV) loading and release was carried out on SBA-15 and functionalized SBA-15. The functionalized and drug loaded mesoporous materials were comprehensively characterized using X-ray diffraction, nitrogen adsorption isotherms, FTIR, TGA, SEM, and TEM techniques. The Box-Behnken design was applied to optimize the variables of drug loading time, ultrasound irradiation time, and carrier dose. Results indicated that the COO− group of SV was associated with the amine group of functionalized SBA-15. SV release was performed in HCl 0.01 M, acetate buffer solution pH = 4.5, and phosphate buffer solution pH = 6.8. The release date indicated that the loading of the aminopropyl group in SBA-15 influenced the release properties of SV. Eventually, the drug release kinetic models were investigated for both carriers. • Mesoporous Santa Barbara amorphous (SBA-15) was functionalized through co‐condensation method. • To optimize the circumstances of drug loading, the Box-Behnken design was implemented. • A comprehensive study of the sodium valproate (SV) loading and release was carried out on SBA-15 and functionalized SBA-15. • The drug release kinetic models were investigated for both carriers. [ABSTRACT FROM AUTHOR]