1. Assessment of insertion/deletion polymorphism of ACE gene as a genetic risk marker for preeclampsia in pregnant women.
- Author
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Gull M, Muharram EI, Shaik NA, Al Mahdi HB, Bondagji NS, and Al Doghaither HA
- Subjects
- Adult, Case-Control Studies, Female, Genetic Markers, Genetic Profile, Humans, Mutagenesis, Insertional, Polymorphism, Genetic, Pregnancy, Saudi Arabia, Sequence Deletion, Blood Pressure Determination methods, Blood Pressure Determination statistics & numerical data, Peptidyl-Dipeptidase A genetics, Pre-Eclampsia diagnosis, Pre-Eclampsia ethnology, Pre-Eclampsia genetics
- Abstract
Objective: To investigate the possible associations of angiotensin converting enzyme insertion or deletion genotypes and alleles with the risk of preeclampsia in Arab women., Methods: The case-control study was conducted from January 2016 to December 2017 at King Abdulaziz University Hospital and Maternity & Children Hospital, Jeddah, Saudi Arabia, and comprised pregnant women withpreeclampsia as cases and normal pregnant women as controls. Deoxyribonucleic acid was extracted and angiotensin-converting enzyme gene was amplified by polymerase chain reaction analysis and characterised through gel electrophoresis., Results: Of the 162 women, 68(42%) were cases and 94(58%) controls. The mean values of age, body mass index, and systolic and diastolic blood pressure were significantly different among the cases than the controls (p<0.05), but mean gestational age did not significantly differ between the groups (p>0.05). The distribution of the polymorphic variants of the angiotensin converting enz yme gene insertion/deletion was not significantly different between the groups (p>0.05). Also, genotype distribution and allelic frequencies were not significantly different between the groups (p>0.05)., Conclusions: For insertion/deletion polymorphism, no significant differences were detected in the genotype and allele frequencies or any of the inheritance models between preeclampsia patients and controls.
- Published
- 2020
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