1. Phytochemistry of compounds isolated from the leaf-surface extract of Psiadia punctulata (DC.) Vatke growing in Saudi Arabia.
- Author
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Dal Piaz F, Bader A, Malafronte N, D'Ambola M, Petrone AM, Porta A, Ben Hadda T, De Tommasi N, Bisio A, and Severino L
- Subjects
- Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Antifungal Agents chemistry, Antifungal Agents isolation & purification, Asteraceae chemistry, Candida albicans drug effects, Diterpenes, Kaurane chemistry, Diterpenes, Kaurane isolation & purification, Flavonoids chemistry, Flavonoids isolation & purification, Microbial Sensitivity Tests, Molecular Structure, Phytochemicals chemistry, Plant Extracts pharmacology, Plant Leaves chemistry, Saudi Arabia, Staphylococcus aureus drug effects, Surface Properties, Anti-Bacterial Agents pharmacology, Antifungal Agents pharmacology, Diterpenes, Kaurane pharmacology, Flavonoids pharmacology, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Extracts chemistry
- Abstract
The surface extract of an accession of Psiadia punctulata (DC.) Vatke (Asteraceae) growing in Saudi Arabia was investigated for its phytochemical composition. A bio-guided investigation of the extract led to the isolation of thirteen ent-kaurane and trachylobane diterpenes and seventeen compounds previously described, including nine flavonoids and eight diterpenes. Three flavonoids and one ent-kaurane diterpene showed antimicrobial activity with MIC100 values ranging from 25 to 150 μg/ml. The extract showed antibacterial activity against Staphylococcus aureus (MIC
100 = 180 μg/ml) and antifungal activity against Candida albicans (MIC0 = 130 μg/ml). The isolated 3',4',5,7-tetramethoxyflavone, at a concentration of 40 μg/ml, displayed the ability to reduce biofilm formation of S. aureus and C. albicans by 50% and 90% respectively., (Copyright © 2018 Elsevier Ltd. All rights reserved.)- Published
- 2018
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