1. Acute myeloid leukemia following Hodgkin lymphoma: a population-based study of 35,511 patients.
- Author
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Schonfeld SJ, Gilbert ES, Dores GM, Lynch CF, Hodgson DC, Hall P, Storm H, Andersen A, Pukkala E, Holowaty E, Kaijser M, Andersson M, Joensuu H, Fosså SD, Allan JM, and Travis LB
- Subjects
- Adult, Antineoplastic Agents administration & dosage, Antineoplastic Agents adverse effects, Confounding Factors, Epidemiologic, Female, Finland epidemiology, Hodgkin Disease drug therapy, Humans, Incidence, Leukemia, Myeloid, Acute chemically induced, Male, Middle Aged, Neoplasms, Second Primary chemically induced, North America epidemiology, Ontario epidemiology, Poisson Distribution, Registries, Research Design, Risk Assessment, SEER Program, Scandinavian and Nordic Countries epidemiology, Hodgkin Disease therapy, Leukemia, Myeloid, Acute epidemiology, Neoplasms, Second Primary epidemiology
- Abstract
Treatments for Hodgkin lymphoma are associated with large relative risks of acute myeloid leukemia (AML), but there are few estimates of the excess absolute risk (EAR), a useful measure of disease burden. One-year Hodgkin lymphoma survivors (N = 35,511) were identified within 14 population-based cancer registries in Nordic countries and North America from January 1, 1970, through December 31, 2001. We used Poisson regression analysis to model the EAR of AML, per 10,000 person-years. A total of 217 Hodgkin lymphoma survivors were diagnosed with AML (10.8 expected; unadjusted EAR = 6.2; 95% confidence interval = 5.4 to 7.1). Excess absolute risk for AML was highest during the first 10 years after Hodgkin lymphoma diagnosis but remained elevated thereafter. In subsequent analyses, adjusted for time since Hodgkin lymphoma diagnosis and presented for the 5-9 year interval, the EAR was statistically significantly (P < .001) larger in patients diagnosed with Hodgkin lymphoma at age 35 years and older than in those diagnosed before 35 years of age. The EAR of AML declined statistically significantly after 1984 (7.0 to 4.2 and 16.4 to 9.9 in the < 35 and > or = 35 age groups, respectively), which may be associated with modifications in chemotherapy.
- Published
- 2006
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