6 results on '"Briggs, J."'
Search Results
2. Renal replacement therapy in Europe: the results of a collaborative effort by the ERA-EDTA registry and six national or regional registries.
- Author
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van Dijk PC, Jager KJ, de Charro F, Collart F, Cornet R, Dekker FW, Grönhagen-Riska C, Kramar R, Leivestad T, Simpson K, and Briggs JD
- Subjects
- Austria epidemiology, Belgium epidemiology, Cause of Death, Europe, Finland epidemiology, France epidemiology, Humans, Kidney Diseases classification, Kidney Diseases epidemiology, Kidney Failure, Chronic epidemiology, Kidney Failure, Chronic mortality, Netherlands epidemiology, Norway epidemiology, Proportional Hazards Models, Renal Replacement Therapy mortality, Renal Replacement Therapy trends, Scotland epidemiology, Survival Analysis, Kidney Failure, Chronic therapy, Registries, Renal Replacement Therapy statistics & numerical data
- Abstract
Background: In June 2000 a new ERA-EDTA Registry Office was opened in Amsterdam. This Registry will only collect core data on renal replacement therapy (RRT) through national and regional registries. This paper reports the technical and epidemiological results of a pilot study combining the data from six registries., Methods: Data from the national renal registries of Austria, Finland, French-Belgium, The Netherlands, Norway, and Scotland were combined. Patients starting RRT between 1980 and 1999 (n=57371) were included in the analyses. Cox proportional hazards regression was used to predict survival., Results: The use of different coding systems for ESRD treatment by the registries made it difficult to merge the data. Incidence and prevalence of RRT showed a continuous increase with a marked variation in rates between countries. The 2-, 5- and 10-year patient survival was 67, 35 and 11% in dialysis patients and 90, 81 and 64% after a first renal allograft. Multivariate analysis showed a slightly better survival on dialysis in the 1990-1994 (RR 0.94, 95% CI 0.90-0.98) and the 1995-1999 cohort (RR 0.88, 95% CI 0.84-0.92) compared to the 1980-1984 cohort. In contrast, there was a much greater improvement in transplant-patient survival, resulting in a 56% reduction in the risk of death within the 1995-1999 cohort (RR 0.44, 95% CI 0.39-0.50) compared to the 1980-1984 cohort., Conclusions: This study provides support for the feasibility of a "new style" ERA-EDTA registry and the collection of data is now being extended to other countries. The improvement in patient survival over the last two decades has been much greater in transplant recipients than in dialysis patients.
- Published
- 2001
- Full Text
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3. Renal replacement therapy in the elderly.
- Author
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Rodger RS and Briggs JD
- Subjects
- Adolescent, Adult, Forecasting, Humans, Middle Aged, Renal Replacement Therapy mortality, Renal Replacement Therapy trends, Scotland epidemiology, Survival Analysis, Aged statistics & numerical data, Kidney Failure, Chronic therapy, Renal Replacement Therapy methods, Renal Replacement Therapy statistics & numerical data
- Abstract
Before 1980 few patients over the age of 65 started chronic dialysis, despite the fact that the incidence of advanced chronic renal failure was approximately ten times greater in this group compared to young and middle aged adults. Since that time the number of elderly patients starting renal replacement has increased markedly and accounted for 38% of new dialysis patients in Scotland in 1995. (Data supplied by the Scottish Renal Registry). In order to meet the needs of older patients with chronic renal failure there has been considerable expansion in renal services and it has been predicted that this will continue to increase in Scotland until 2010.
- Published
- 1997
- Full Text
- View/download PDF
4. Crescentic glomerulonephritis: experience of a single unit over a five year period.
- Author
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Jeffrey RF, Gardiner DS, More IA, Junor BJ, and Briggs JD
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Hospital Units, Humans, Immunosuppressive Agents administration & dosage, Immunosuppressive Agents adverse effects, Kidney Failure, Chronic mortality, Kidney Failure, Chronic therapy, Male, Middle Aged, Retrospective Studies, Scotland, Glomerulonephritis etiology, Glomerulonephritis mortality, Glomerulonephritis pathology, Glomerulonephritis physiopathology
- Abstract
Crescentic glomerulonephritis is a well defined pathological lesion occurring in a range of renal and systemic diseases. We have retrospectively reviewed the aetiology, clinical features and outcome in 60 patients presenting over a five and a half year period. Most patients were elderly (median age 61 years, range 16-84 years). The majority presented with severe renal impairment, 32 requiring dialysis at admission. The degree of glomerular crescent formation on biopsy was closely related both to initial dialysis dependence and the ensuing response to immunosuppression. Forty-three patients received immunosuppressive treatment. A beneficial response was seen in 40% of patients requiring dialysis, and in 88% of those with less severe renal impairment. A high early mortality was apparent (30% within three months), exclusively affecting elderly patients (all > 60 years), with advanced renal failure (all dialysis dependent), the majority of whom (15 out of 18) had been immunosuppressed. The results suggest that the benefits of immunosuppression in this group may be outweighed by the complications of treatment.
- Published
- 1992
- Full Text
- View/download PDF
5. Dialysis at home in the west of Scotland: a comparison of hemodialysis and continuous ambulatory peritoneal dialysis in age- and sex-matched controls.
- Author
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Grant AC, Rodger RS, Howie CA, Junor BJ, Briggs JD, and Macdougall AI
- Subjects
- Actuarial Analysis, Adult, Cardiovascular Diseases epidemiology, Female, Humans, Kidney Failure, Chronic epidemiology, Kidney Transplantation statistics & numerical data, Male, Retrospective Studies, Risk Factors, Scotland epidemiology, Smoking epidemiology, Treatment Outcome, Hemodialysis, Home, Kidney Failure, Chronic therapy, Peritoneal Dialysis, Continuous Ambulatory
- Abstract
Objective: To audit the outcome of patients treated at home by hemodialysis and continuous ambulatory peritoneal dialysis (CAPD)., Design: Retrospective comparison of nondiabetic hemodialysis patients with age- and sex-matched nondiabetic patients treated by CAPD., Setting: Renal Units, Stobhill General Hospital and Western Infirmary, Glasgow, providing the home dialysis service for the West of Scotland., Patients: Between 1982 and 1988, 139 hemodialysis patients starting treatment at home, compared with 139 matched patients starting CAPD over the same time period., Main Outcome Measures: Patient characteristics and cardiovascular risk factors at the start of home treatment. Patient and technique survival with both forms of dialysis., Results: Patients selected for home hemodialysis were less likely to be smokers (p < 0.02) and to have electrocardiographic evidence of ischemia or left ventricular hypertrophy (p < 0.05) than patients treated by CAPD. Patient survival and technique survival (excluding death and renal transplantation) at 3 years were 93.8% versus 86.2% (p < 0.05) and 94.2% versus 80.8% (p < 0.04) for hemodialysis and CAPD, respectively. Cardiovascular events were responsible for the majority of deaths in both groups, but there was a greater proportion of deaths from other causes in patients treated by CAPD. There was no significant difference in the transplantation rate between the two treatment groups., Conclusions: Home dialysis is an effective method of renal replacement treatment for patients with end-stage renal disease. The results of hemodialysis are superior to CAPD, but this may be partly due to selection bias.
- Published
- 1992
6. Cancer, warts, and sunshine in renal transplant patients. A case-control study.
- Author
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Boyle J, MacKie RM, Briggs JD, Junor BJ, and Aitchison TC
- Subjects
- Adult, Carcinoma, Basal Cell epidemiology, Carcinoma, Squamous Cell epidemiology, Dermatomycoses epidemiology, Female, Herpes Simplex epidemiology, Herpes Zoster epidemiology, Humans, Immunosuppression Therapy adverse effects, Keratosis epidemiology, Male, Scotland, Ultraviolet Rays adverse effects, Kidney Transplantation, Skin Diseases epidemiology, Skin Neoplasms epidemiology, Sunlight adverse effects, Warts epidemiology
- Abstract
94 renal transplant patients were examined for the presence of cutaneous malignancies, actinic keratoses, warts, and cutaneous fungal infection, and a history was taken of infection with herpes simplex and herpes zoster. Each patient had a control matched for age, sex, and sun exposure. Of the 17 patients with high exposure to sunshine (more than 3 months in a tropical or subtropical climate or more than 5 years in an outdoor occupation), 2 had squamous cell carcinoma and 7 actinic keratoses. These lesions did not occur in the other renal transplant patients or the control group. The immunosuppressive effect of ultraviolet radiation in the sunburn spectrum (290-320 nm) in man and animals may be related to the increased incidence of cutaneous malignancy, actinic keratoses, and warts. Transplant patients should be under regular surveillance for the early detection and treatment of premalignant cutaneous lesions, and they should receive advice on avoiding sun exposure.
- Published
- 1984
- Full Text
- View/download PDF
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