1. Association Between Zika Virus Microcephaly in Newborns With the rs3775291 Variant in Toll-Like Receptor 3 and rs1799964 Variant at Tumor Necrosis Factor-α Gene.
- Author
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Santos, Camilla N O, Ribeiro, Danielle R, Alves, Juliana Cardoso, Cazzaniga, Rodrigo A, Magalhães, Lucas S, Souza, Mércia S F de, Fonseca, Adriana B L, Bispo, Ana J B, Porto, Roseane L S, Santos, Cliomar Alves dos, Silva, Ângela M da, Teixeira, Mauro M, Almeida, Roque P de, Jesus, Amélia R de, Cardoso, Juliana A, de Souza, Mércia S F, Alves Dos Santos, Cliomar, da Silva, Ângela M, de Almeida, Roque P, and Cardoso Alves, Juliana
- Subjects
TOLL-like receptors ,ZIKA virus ,TYPE I interferons ,NECROSIS ,POLYMERASE chain reaction - Abstract
Congenital Zika syndrome (CZS) is a cluster of malformation, and the mechanisms that lead it are still unclear. Using hypothesis-driven candidate genes and their function in viral infections, single-nucleotide polymorphisms (SNPs) were genotyped by quantitative polymerase chain reaction in a sample population from Sergipe State, Brazil. This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon antiviral responses in mothers infected by Zika virus during pregnancy, is associated with CZS occurrence (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.158-4.148). Moreover, rs1799964 SNP at tumor necrosis factor-α gene in CZS babies is associated with severe microcephaly (OR, 2.63; 95% CI, 1.13-6.21). [ABSTRACT FROM AUTHOR]
- Published
- 2019
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