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Your search keyword '"NEOPLASTIC cell transformation"' showing total 5 results
Start Over Descriptor "NEOPLASTIC cell transformation" Region shanghai (china)
5 results on '"NEOPLASTIC cell transformation"'

1. New Findings from Shanghai Jiao Tong University Describe Advances in Prostate Cancer (Acetylated Khsrp Impairs Dna-damage-response-related Mrna Decay and Facilitates Prostate Cancer Tumorigenesis).

Subjects
PROSTATE cancer, MESSENGER RNA, DNA repair, NEOPLASTIC cell transformation, DNA, MOLECULAR oncology
Abstract

A study conducted by researchers at Shanghai Jiao Tong University in China has found that acetylated KHSRP, an RNA-binding protein, impairs the mRNA decay of DNA damage response (DDR)-related genes and promotes the development of prostate cancer. The study also discovered that androgen stimulation increases the acetylation of KHSRP, which inhibits its interaction with the deacetylase SIRT7 and further enhances KHSRP acetylation. These findings provide insights into the biology of KHSRP and potential therapeutic strategies for the treatment of prostate cancer, including castration-resistant prostate cancer. [Extracted from the article]

Published
2024

2. Recent Findings from Shanghai Jiao Tong University Provides New Insights into Cancer (Setd2 Deficiency Promotes Gastric Tumorigenesis Through Inhibiting the Sirt1/foxo Pathway).

Subjects
NEOPLASTIC cell transformation, INTESTINAL tumors, METHYLTRANSFERASES, ELECTRONIC records
Abstract

A recent report from Shanghai Jiao Tong University in China explores the role of SETD2 deficiency in gastric cancer. Gastric cancer is a common and deadly form of cancer, and SETD2 is a histone methyltransferase involved in various biological processes and human tumors. The study found that SETD2 deficiency predicts a poor prognosis for gastric cancer patients and promotes gastric tumorigenesis. The researchers discovered that SETD2 depletion impairs the epigenetic regulation of Sirt1, inhibiting the SIRT1/FOXO pathway. These findings provide new insights into the mechanisms of gastric cancer and may lead to the development of targeted therapies for patients with SETD2 deficiency. [Extracted from the article]

Published
2024

3. Findings from Shanghai Jiao Tong University in the Area of Clinical Oncology Described (Mettl14 Modulates Glycolysis To Inhibit Colorectal Tumorigenesis In P53-wild-type Cells).

Subjects
GLYCOLYSIS, ONCOLOGY, NEOPLASTIC cell transformation, TUMOR growth, NEWSPAPER editors
Abstract

In this study, we show that METTL14 is transcriptionally activated by wild-type p53 and suppresses tumor growth only in p53-wild-type (p53-WT) CRC cells. METTL14 deletion promotes both AOM/DSS and AOM-induced CRC growth in mouse models with the intestinal epithelial cell-specific knockout of METTL14. [Extracted from the article]

Published
2023

5. Drinking Water Disinfection Byproduct Iodoacetic Acid Induces Tumorigenic Transformation of NIH3T3 Cells.

Author

Xiao Wei, Shu Wang, Weiwei Zheng, Xia Wang, Xiaolin Liu, Songhui Jiang, Jingbo Pi, Yuxin Zheng, Gengsheng He, and Weidong Qu

Subjects
*WATER disinfection, *DISINFECTION by-product, *ORGANOIODINE compounds, *ACETIC acid, *IODOFORM, *TOXICOLOGY, *NEOPLASTIC cell transformation, *DRINKING water analysis, *CONTAMINATION of drinking water
Abstract

Iodoacetic acid (IAA) and iodoform (IF) are unregulated iodinated disinfection byproducts (DBPs) found in drinking water. Their presence in the drinking water of China has not been documented. Recently, the carcinogenic potential of IAA and IF has been a concern because of their mutagenicity in bacteria and genotoxicity in mammalian cells. Therefore, we measured their concentrations in Shanghai drinking water and assessed their cytotoxicity, genotoxicity, and ability to transform NIH3T3 cells to tumorigenic lines. The concentrations of IAA and IF in Shanghai drinking water varied between summer and winter with maximum winter levels of 2.18 μg/L IAA and 0.86 μg/L IF. IAA with a lethal concentration 50 (LC50) of 2.77 μM exhibited more potent cytotoxicity in NIH3T3 cells than IF (LC50 = 83.37 μM). IAA, but not IF, induced a concentration-dependent DNA damage measured by γ-H2AX staining and increased tail moment in single-cell gel electrophoresis. Neither IAA nor IF increased micronucleus frequency. Prolonged exposure of NIH3T3 cells to IAA increased the frequencies of transformed cells with anchorage-independent growth and agglutination with concanavalin A. IAA-transformed cells formed aggressive fibrosarcomas after inoculation into Balb/c nude mice. This study demonstrated that IAA has a biological activity that is consistent with a carcinogen and human exposure should be of concern. [ABSTRACT FROM AUTHOR]

Published
2013
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