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Background: Inflammatory and non‐inflammatory acne lesions constitute a significant clinical challenge in acne subjects. Aim: To evaluate the efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid for improving skin conditions. Methods: This randomized controlled trial included adults with comedones, post‐inflammatory erythema (PIE) and/or hyperpigmentation (PIH) in Shanghai, China in July 2021. Participants were randomly assigned 1:1 to receive the study Serum + Mask or serum alone for 8 weeks. Acne severity, comedones, papules, pustules, PIE, PIH, skin pores, skin tone evenness, sebum secretion, skin hydration, and trans‐epidermal water loss were evaluated at T0d, T1d, T7d, T14d, T28d, and T56d. Results: Eighty‐three participants were included, including 41 and 42 in the Serum + Mask and Serum groups, respectively. Acne severity, density of skin pores, skin tone evenness, PIH foci on face, PIE foci on nose, intensity of PIE and PIH, closed comedones on face, open comedones on nose, sebum secretion, and skin hydration were significantly improved from baseline after 8 weeks of treatment in both groups (all p < 0.05). Addition of the mask improved the number of closed comedones (−6.56 ± 0.39 vs. −5.19 ± 0.44, p = 0.022) and acne severity (−0.39 ± 0.08 vs. −0.12 ± 0.09, p = 0.026) substantially more than using the serum alone. No adverse reaction was reported in either group. Conclusions: The study serum improved skin conditions by regulating skin barrier function and achieving a balance of skin hydration and sebum secretion, removing comedones and improving PIE and PIH. Addition of the mask accelerated the effects without compromising safety. [ABSTRACT FROM AUTHOR]

Background: Late bedtime is a common form of unhealthy sleep pattern in adulthood, which influences circadian rhythm, and negatively affects health. However, little is known about the effect of regular late bedtime on skin characteristics, particularly on skin microbiome. Objective: To investigate the changes and effects of the regular late bedtime on skin physiological parameters and facial bacterial microbiome of 219 cases of Chinese women aged 18– 38 years living in Shanghai. Methods: Based on the Self-Evaluation Questionnaire, bedtime was categorized as 11:00 PM; thus, the volunteers were divided into early bedtime group (S0) and late bedtime group (S1). The physiological parameters of facial skin were measured by non-invasive instrumental methods, and the skin microbiome was analyzed by 16S rRNA high-throughput sequencing. Results: The skin physiological parameters of the late bedtime group exhibited significant decrease in skin hydration content, skin firmness (F4) and elasticity (R2), while TEWL, sebum and wrinkle significantly increased. The result indicated that late bedtime significantly impaired the integrity of skin barrier, damaged skin structure, and disrupted water–oil balance. Furthermore, the analysis of α-diversity, Sobs, Ace and Chao index were found to significantly decrease (P < 0.05) in the late bedtime group, suggesting that late bedtime reduced both the abundance and the diversity of facial bacterial microbiota. Moreover, the abundance of Pseudomonas increased significantly, while Streptococcus, Stenotrophomonas, Acinetobacter, Haemophilus, Actinomyces and Neisseria decreased significantly. In addition, Spearman correlation analysis revealed strong correlations between the microbiota and the physiological parameters. Notably, the abundance of Pseudomonas significantly positively correlated with skin firmness and elasticity, but significantly negatively correlated with skin hemoglobin content, melanin content and skin hydration. Conclusion: Bedtime is an important factor in maintaining skin health. Regular late bedtime not only damages the skin barrier and skin structure but also reduces the diversity and composition of facial bacterial microbiome. [ABSTRACT FROM AUTHOR]

Background: Although Sensitive skin (SS) conditions are reported to be affected by climate changes, the correlations with meteorological parameters remain mostly unclear. Objective: To investigate the changes of facial skin conditions in different seasons in Shanghai, including the speed and severity of the influences imposed by different meteorological parameters. Methods: Totally eighty-one healthy female volunteers completed the study in both spring (May) and summer (August). Evaluations of facial skin conditions included stimulating sensory test, clinical grading and biophysical measurements. Correlations between the meteorological parameters and ΔTEWL as well as clinical parameters were analyzed. Results: There was no significant difference between two seasons in lactic acid sting test. The stimulation sensations felt by Vitamin B3 (VB3) containing cream was significantly higher in May than that in August. In accordance, baseline visual scores for erythema and scaliness in May were also significantly higher than those scores in August. The baseline transepidermal water loss (TEWL) value was significantly higher in May than that in August. Positive correlations were detected between ΔTEWL and atmospheric pressure on the test day, adjust 3-day and 7-day mean of daily solar radiation respectively. There were negative correlations between ΔTEWL and temperature outside on the test day, adjust 3-day mean as well as adjust 7-day mean of relative humidity. Conclusions: Facial skin conditions in summer are better than that in spring in Shanghai. The influences from atmospheric pressure and temperature are relatively quick in speed, while the influences from relative humidity and solar radiation are slow but cumulative. [ABSTRACT FROM AUTHOR]