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Background: Patients diagnosed with pulmonary tuberculosis (TB) have poor sleep quality due to multiple factors. We aimed to assess the sleep status and related factors of TB patients in Shenzhen, China. Methods: A questionnaire survey was conducted on 461 TB patients hospitalized at Shenzhen Third People's Hospital from March 2021 to January 2022, and sleep quality was assessed using the Pittsburgh sleep quality index (PSQI). Results: A total of 459 valid questionnaires were collected, and 238 of the 459 TB patients had general or poor sleep quality (PSQI > 5). Patients' gender, marriage, nutritional screening score, family atmosphere, fear of discrimination, fear of interactions, and the impact of the disease on their work life had significant effects on sleep quality (P < 0.05); PSQI scores of TB patients were negatively correlated with lymphocyte counts (r = − 0.296, P < 0.01), T-lymphocyte counts (r = − 0.293, P < 0.01), helper T lymphocyte counts (r = − 0.283, P < 0.01), killer T lymphocyte counts (r = − 0.182, P < 0.05), and were positively correlated with depression scores (r = 0.424, P < 0.01). Multivariable logistic regression analysis showed that male (OR = 1.64,95% CI 1.11–2.42, P < 0.05), unmarried (OR = 1.57, 95% CI 1.02–2.42, P < 0.05), NRS score grade 3(OR = 5.35, 95% CI 2.08–15.73, P < 0.01), general family atmosphere (OR = 2.23, 95% CI 1.07–4.93, P < 0.05), and the disease affecting work (OR = 1.66, 95% CI 1.11–2.50, P < 0.05) were factors influencing poor sleep quality. Conclusion: Most TB patients had varying degrees of sleep disturbance, which may be affected by their gender, marriage, family atmosphere, nutritional status, the effect of the disease on work life, and, depression, as well as lower absolute T-lymphocyte subpopulation counts. Appropriate interventions should be implemented to improve their sleep quality, when treating or caring for such patients. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study is to identify factors affecting medical follow-up adherence of pulmonary multidrug-resistant tuberculosis (MDR-TB) patients on an all-oral regimen in Shenzhen, China to enhance intervention measures for increased treatment success. Methods: A cohort study was conducted in The Third People's Hospital of Shenzhen on MDR-TB patients switched to an all-oral regimen to evaluate effectiveness following the WHO's recommendation in late 2018. We recruited patients in the group for an opinion survey on medical follow-up adherence from May 2019 to June 2020. The survey was designed with socio-demographic questions in collecting baseline characteristics and importance and Likert closed-ended questions for measuring opinions and relevance of different factors to adherence. Linear regression model was used to analyze data collected. Results: The findings revealed that gender difference (P = 0.828) had no correlation with adherence. Marital status (P = 0.014), financial situation (P < 0.001) and difficulties encountered with medical appointment booking procedures (P = 0.001) were significantly associated with medical follow-up adherence. Single (including widowed and divorced) patients, those with low household income and patients having difficulties making online medical appointment booking, were at higher risk of defaulting from routine MDR-TB medical follow-up. Conclusion: Our survey revealed that financial burden, being single and a non-user friendly medical appointment booking system are the main barriers to patients' medical follow-up compliance. More financial assistance, better patient support and simplifying medical appointment booking procedures are facilitators of better treatment adherence. [ABSTRACT FROM AUTHOR]