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OBJECTIVE: To probe into the guiding function of dexmedetomidine combined with EEG bimodal index monitoring on awake timing of laryngeal mask removal under general anesthesia and its effect on complications in children. METHODS Totally 150 children undergoing surgery with general anesthesia admitted into the Third Hospital of Shijiazhuang from Jul. 2018 to Jul. 2020 were selected for EGG bimodal index monitoring, all the children were divided into control group (75 cases, given laryngeal mask removal when EGG bimodal index was 60-65) and observation group(75 cases, given laryngeal mask removal when EGG bimodal index was 75-80). Dexmedetomidine was applied on both groups during surgery, the mean arterial pressure, heart rate, oxygen saturation (SpO2) and systolic blood pressure(SBP) levels before and after extubation were compared between two groups, the incidences of complications of two groups were observed and recorded, and the overall satisfaction rate were compared between two groups. RESULTS: The differences in mean arterial pressure and heart rate between two groups were not statistically significant (P > 0. 05); compared with the control group, the mean arterial pressure and heart rate of children undergoing general anesthesia after extubation were higher in the observation group, with statistically significant differences (P<0. 05). There were no statistical significance in differences in the preoperative SpO2, SBP level and SBP level after extubation between two groups of children undergoing surgery with general anesthesia (P > 0. 05); compared with the control group, the SpO2 level of children undergoing surgery with general anesthesia after extubation was higher in the observation group, with statistically significant difference (P < 0. 05). There was no statistical significance in difference in the incidence of complications such as choking, breath-holding, SpO2 < 93% and laryngospasm after extubation between two groups of children undergoing surgery with general anesthesia (P>0. 05). Compared with the control group, the overall satisfaction rate of children undergoing surgery with general anesthesia was higher in the observation group, with statistically significant difference(P<0. 05). CONCLUSIONS: The effect of laryngeal mask removal under dexmedetomidine combined with EGG bimodal index of 75-80 is better than that of the EEG bimodal index of 60-65, which is of great significance in reducing the incidences of complication and ensuring the safety in extubation period. [ABSTRACT FROM AUTHOR]