1. Retro- and prospective evaluation of dynamics of some mutational events.
- Author
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Bochkov NP, Grigorian SD, Lunga IN, Nikolaeva IV, Prussakov VM, and Tikhopoy MV
- Subjects
- Abnormalities, Multiple epidemiology, Abortion, Spontaneous epidemiology, Down Syndrome epidemiology, Female, Humans, Infant, Newborn, Models, Genetic, Pregnancy, Prospective Studies, Retrospective Studies, Siberia, Abnormalities, Multiple genetics, Abortion, Spontaneous genetics, Down Syndrome genetics, Mutation
- Abstract
The dynamics of some mutational events were studied in a Siberian town with a chemical industry. Retro- and prospective evaluations of the frequency of spontaneous abortions, multiple congenital malformations, and Down syndrome were carried out. Mutational components of these endpoints were summarized and provisionally termed "units of mutational events" (UME). The results show that the frequencies of UME have not changed in 14 years.
- Published
- 1986
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