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Mapping soil heavy metal concentration using machine learning models based on readily available satellite remote sensing images is highly desirable. Accurate mapping relies on appropriate data, feature extraction, and model selection. To this end, a data processing pipeline for soil copper (Cu) concentration estimation has been designed. First, instead of using single Landsat scenes, the utilization of multiple Landsat scenes of the same location over time is considered. Second, to generate a preferred feature set as input to a regression model, a number of feature extraction methods are motivated and compared. Third, to find a preferred regression model, a variety of approaches are implemented and compared for accuracy. In this research, 11 Landsat-8 images from 2013 to 2017 of Gulin County, Sichuan China, and 138 soil samples with lab-measured Cu concentrations collected from the area in 2015 are used. A variety a metrics under cross-validation are used for comparison. The results indicate that multi-temporal images increase accuracy compared to single Landsat images. The preferred feature extraction varies based on the regression model used; however, the best results are obtained using support vector regression and the original data. The final soil Cu map generated using the recommended data processing pipeline shows a consistent spatial pattern with a ground-truth land cover classification map. These results indicate that machine learning has the ability to perform large-scale soil heavy metal mapping from widely available satellite remote sensing images. [ABSTRACT FROM AUTHOR]