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To analyze the serotype distribution and drug resistance of Streptococcus pneumoniae isolated from hospitalized patients of all ages in Zhongjiang county, Sichuan province, where the young children have just begun to vaccinate the PCV13 in private sector. Serotypes were determined for 387 isolates of S. pneumoniae by Quellung reaction. Antibiotic susceptibility was tested with the E-test or disc diffusion method. The most common serotypes were type 19F and confirmed for 88 isolates (22.7%), followed by 19A (15.0%), 6B (7.8%), 16F (7.8%), 23F (7.0%) and 15A (4.4%). The coverage rates of PCV13 and PPSV23 were 63.3% and 65.1%. With the increase of age, the proportion of PCV13 types decreased significantly, from 71.3% (<2 years old) to 41.9% (≥60 years old). The intermediate rate and resistance rate of the isolates to oral penicillin were 48.6% and 45.2%, respectively. The resistance rate of erythromycin was high (94.4%). The PCV13 isolates was more resistant to penicillin than the non-PCV13 ones. The PCV13 coverage rate in pediatric isolates was higher than those in adult isolates. The adults, especially the elderly, may be the reservoir of non-PCV13 types. It is necessary to investigate the serotype distribution of S. pneumoniae based on all age population to assess potential epidemics of non-vaccine serotype associated with PCVs administration. [ABSTRACT FROM AUTHOR]

As a necessary work before risk prevention and control, risk assessment has become increasingly important in multimodal transport networks. On the basis of the idea of quality function deployment (QFD), this paper combines fuzzy G1 method, two‐tuple linguistic representation model, and dynamic intuitionistic fuzzy multi‐attribute evaluation method to propose a new method for risk assessment. QFD is innovatively used to create an overall framework, which includes the basic importance rating of risk factors, the correlation between risk factors and network failures, the importance rating of network failures, and the comprehensive importance rating of risk factors. The comprehensive importance rating is regarded as an indicator to verify, improve, and modify the basic importance rating, which can make up for the disadvantage of the existing risk assessment methods in proving the credibility of the results. Its result is the key to judging the degree of influence of risk factors on network operation. This paper takes the multimodal transport network in the Sichuan–Tibet region of China as an example for analysis. The results are analyzed and discussed to prove the validity and advancement of the proposed method. [ABSTRACT FROM AUTHOR]