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• A zoning method based on ecological indicators and economic indicators is applied. • Ecological and economic situations are highly correlated with topographic conditions. • The coupling coordination degree(CCD) between ecology and economy is calculated. • Economic development is highly positively correlated with CCD. • Targeted regional sustainable development strategies are put forward. The coordinated development of ecology and economy is one of the key issues of sustainable development. A full understanding of the relationship between ecology and economy is necessary for the coordinated development of the two. This paper takes Sichuan Province as the research area and county-level administrative districts as the research unit. Based on the medium value of the ecological quality index and economic growth index of each unit, Sichuan Province is divided into dual pressure zones (DPZ), economic backward zones (EBZ), ecological crisis zones (ECZ), and coordinated development zones (CDZ) and the coupling coordination degree (CCD) of each unit is studied. The results show that: (1) On the whole, the eastern part of Sichuan Province has a better level of economic development, and the southern part of the western region has a higher ecological quality. The ecological quality and economic growth pattern are highly correlated with topographical conditions. (2) The distribution characteristics of the four types of partitions are significantly different. The EBZ are more distributed in the western and southern of Sichuan Province, the ECZ are more distributed in the eastern, the DPZ and CDZ are relatively more sporadic. More than 90% of the partition changed zones are distributed in the eastern area. (3) The CCD of more than 95% units belongs to moderate coordination and high coordination. The overall CCD of the four types of zones has shown an upward trend from 2010 to 2015. Based on the results, Sichuan Province should follow the path of clear waters and green mountains are as good as mountains of gold and silver, and targeted sustainable development suggestions for DPZ, EBZ, ECZ, and CDZ are put forward. This paper provides guidance for formulating regional sustainable development strategies, especially in areas with unbalanced development due to congenital topographical conditions. [ABSTRACT FROM AUTHOR]