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During the first wave of COVID-19 infection in Italy, the number of cases and the mortality rates were among the highest compared to the rest of Europe and the world. Several studies demonstrated a severe clinical course of COVID-19 associated with old age, comorbidities, and male gender. However, there are cases of virus infection resistance in subjects living in close contact with infected subjects. Thus, to explain the predisposition to virus infection and to COVID-19 disease progression, we must consider, in addition to the genetic variability of the virus and other environmental or comorbidity conditions, the allelic variants of specific human genes, directly or indirectly related to the life cycle of the virus. Here, we analyzed three human genetic polymorphisms belonging to the TMPRSS2 and CCR5 genes in a sample population from Sicily (Italy) to investigate possible correlations with the resistance to viral infection and/or to COVID-19 disease progression as recently described in other human populations. Our results did not show any correlations of the rs35074065, rs12329760, and rs333 polymorphisms with SARS-CoV-2 infection or with COVID-19 disease severity. Further studies on other human genetic polymorphisms should be performed to identify the major human determinants of SARS-CoV-2 viral resistance. [ABSTRACT FROM AUTHOR]

A geologic and geodetic integrated analysis of the northern margin of the Hyblean Plateau (SE Sicily) has been carried out in order to test the relationship between the active deformation, recorded by GPS data, and the long-term tectonic evolution, reconstructed by the interpretation of structural and morphological data. Our study revealed the active growth of a large antiform, as a consequence of the positive tectonic inversion of the previous flexure, bordering the Hyblean Foreland. The deformation of Middle–Late Pleistocene marine terraces and the evolution of the drainage system are consistent with a progressive regional tilting of the entire eastern sector of the Hyblean Plateau (Siracusa Domain), representing the southern limb of the active antiform. The geometry of the Late Quaternary marine strandlines, compared with the results of analogue models, is compatible with the effects of the NW-ward propagation of a detachment fault at depth. The active deformation of the Hyblean region, coherent with the Nubia–Eurasia plate convergence, suggests to candidate the inverted tectonics at the northern border of the Hyblean Plateau as potential seismogenic sources of the area. [ABSTRACT FROM AUTHOR]