1. Clinical and Virological Characteristics of Ebola Virus Disease Patients Treated With Favipiravir (T-705)--Sierra Leone, 2014.
- Author
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Chang-Qing Bai, Jin-Song Mu, Kargbo, David, Ya-Bin Song, Wen-Kai Niu, Wei-Min Nie, Kanu, Alex, Wei-Wei Liu, Yao-Ping Wang, Dafae, Foday, Tao Yan, Yi Hu, Yong-Qiang Deng, Hui-Jun Lu, Fan Yang, Xiao-Guang Zhang, Yang Sun, Yu-Xi Cao, Hao-Xiang Su, and Yu Sun
- Subjects
TREATMENT of Ebola virus diseases ,VIROLOGY ,EPIDEMICS ,PUBLIC health ,ANTIVIRAL agents ,DRUG development - Abstract
Background. During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts of West Africa. No approved antiviral drugs are available for Ebola treatment currently. Methods. A retrospective clinical case series was performed for EVD patients in Sierra Leone-China Friendship Hospital. Patients with confirmed EVD were sequentially enrolled and treated with either World Health Organization (WHO)-recommended supportive therapy (control group) from 10 to 30 October, or treated with WHO-recommended therapy plus favipiravir (T-705) from 1 to 10 November 2014. Survival and virological characteristics were observed for 85 patients in the control group and 39 in the T-705 treatment group. Results. The overall survival rate in the T-705 treatment group was higher than that of the control group (56.4% [22/39] vs 35.3% [30/85]; P = .027). Among the 35 patients who finished all designed endpoint observations, the survival rate in the T-705 treatment group (64.8% [11/17]) was higher than that of the control group (27.8% [5/18]). Furthermore, the average survival time of the treatment group (46.9 ± 5.6 days) was longer than that of the control group (28.9 ± 4.7 days). Most symptoms of patients in the treatment group improved significantly. Additionally, 52.9% of patients who received T-705 had a >100-fold viral load reduction, compared with only 16.7% of patients in the control group. Conclusions. Treatment of EVD with T-705 was associated with prolonged survival and markedly reduced viral load, which makes a compelling case for further randomized controlled trials of T-705 for treating EVD. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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