1. Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses.
- Author
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Jiang T, Jiang JF, Deng YQ, Jiang BG, Fan H, Han JF, Hu Y, Zhuang DM, Kargbo D, An XP, Mi ZQ, Zhao GY, Xin WW, Tan YF, He J, Gao RB, Wang H, Chen C, Wang F, Li CX, Zhao JJ, Cui YJ, Bei ZC, Zhang K, Shang XY, Zhang WH, Pei GQ, Wang YF, Wang W, Shu P, Liu WL, Cheng S, Zhu SY, Kanu A, Kargbo B, Gao B, Tong YG, Fang TY, and Cao WC
- Subjects
- Antibodies, Viral blood, Cytokines blood, Disease Outbreaks, Genome, Viral, Humans, Sierra Leone epidemiology, Survivors, Ebolavirus genetics, Hemorrhagic Fever, Ebola epidemiology, Hemorrhagic Fever, Ebola immunology, Viral Load
- Abstract
We performed Ebola virus disease diagnosis and viral load estimation for Ebola cases in Sierra Leone during the late stage of the 2014-2015 outbreak (January-March 2015) and analyzed antibody and cytokine levels and the viral genome sequences. Ebola virus disease was confirmed in 86 of 1001 (9.7%) patients, with an overall case fatality rate of 46.8%. Fatal cases exhibited significantly higher levels of viral loads, cytokines, and chemokines at late stages of infection versus early stage compared with survivors. The viruses converged in a new clade within sublineage 3.2.4, which had a significantly lower case fatality rate., (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
- Published
- 2017
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