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1. Targeting both rs12979860 and rs8099917 polymorphisms with a single-tube high-resolution melting assay for IL28b genotyping.

Author

Poon KS, Ho SS, Tang JW, Chua CW, Chiu L, and Koay ES

Subjects
Genotype, Haplotypes, Hepacivirus classification, Hepacivirus genetics, Hepacivirus isolation & purification, Hepatitis C virology, Humans, Interferons, Nucleic Acid Denaturation, Singapore, Transition Temperature, Clinical Laboratory Techniques methods, Hepatitis C drug therapy, Interleukins genetics, Molecular Diagnostic Techniques methods, Polymorphism, Single Nucleotide
Abstract

A rapid, duplex, high-resolution melting interleukin-28B gene (IL28B) genotyping assay, targeting both rs12979860 and rs8099917 polymorphisms, was developed and validated using 30 DNA samples from healthy volunteers. A linkage study on 300 healthy Singaporeans showed variable haplotypes. When the assay was applied to plasma DNA from 50 hepatitis C virus genotype-1 (HCV-1)-infected patients, five compound heterozygous types were detected.

Published
2012
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