1. Whole genome sequencing suggests transmission of Corynebacterium diphtheriae -caused cutaneous diphtheria in two siblings, Germany, 2018.
- Author
-
Berger A, Dangel A, Schober T, Schmidbauer B, Konrad R, Marosevic D, Schubert S, Hörmansdorfer S, Ackermann N, Hübner J, and Sing A
- Subjects
- Amoxicillin therapeutic use, Anti-Bacterial Agents therapeutic use, Child, Clavulanic Acid therapeutic use, DNA, Bacterial isolation & purification, DNA, Bacterial metabolism, Diphtheria drug therapy, Diphtheria transmission, Female, Germany, Humans, Real-Time Polymerase Chain Reaction, Siblings, Somalia, Travel, Treatment Outcome, Whole Genome Sequencing, Corynebacterium diphtheriae genetics, Corynebacterium diphtheriae isolation & purification, Diphtheria diagnosis, Diphtheria Toxin genetics, High-Throughput Nucleotide Sequencing methods
- Abstract
In September 2018, a child who had returned from Somalia to Germany presented with cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child's sibling had superinfected insect bites harbouring also toxigenic C. diphtheriae . Next generation sequencing (NGS) revealed the same strain in both patients suggesting very recent human-to-human transmission. Epidemiological and NGS data suggest that the two cutaneous diphtheria cases constitute the first outbreak by toxigenic C. diphtheriae in Germany since the 1980s.
- Published
- 2019
- Full Text
- View/download PDF