1. Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens.
- Author
-
Meyer JJ, Afolayan AJ, Taylor MB, and Erasmus D
- Subjects
- Animals, Antiviral Agents isolation & purification, Carcinoma, Hepatocellular pathology, Cells, Cultured, Flavonoids isolation & purification, Haplorhini, Humans, Kidney cytology, Liver Neoplasms pathology, Mutagens isolation & purification, Plant Shoots chemistry, Plant Shoots metabolism, Plants, Medicinal chemistry, South Africa, Tumor Cells, Cultured, Adenoviruses, Human drug effects, Antiviral Agents pharmacology, Enterovirus B, Human drug effects, Flavonoids pharmacology, Herpesvirus 1, Human drug effects, Plant Extracts pharmacology, Reoviridae drug effects
- Abstract
The in vitro antiviral activity of galangin (3,5,7-trihydroxyflavone), the major antimicrobial compound isolated from the shoots of Helichrysum aureonitens, was investigated against herpes simplex virus type 1 (HSV-1), coxsackie B virus type 1 (Cox B1), adenovirus type 31 (Ad31) and reovirus. At concentrations ranging from 12-47 micrograms/ml galangin showed significant antiviral activity against HSV-1 and CoxB1, limited activity against reovirus, and no antiviral activity against Ad31.
- Published
- 1997
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