1. Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study.
- Author
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Liebenberg, Lenine J P, Passmore, Jo Ann S, Osman, Farzana, Jewanraj, Janine, Mtshali, Andile, Garcia-Lerma, J Gerardo, Heneine, Walid, Holder, Angela, Archary, Derseree, Ngcapu, Sinaye, Sivro, Aida, Mansoor, Leila E, Karim, Quarraisha Abdool, Karim, Salim S Abdool, and McKinnon, Lyle R
- Subjects
DRUG efficacy ,CYTOKINES ,FLOW cytometry ,TENOFOVIR ,INFLAMMATION ,GENITAL diseases ,PHARMACEUTICAL gels - Abstract
Genital inflammation (GI) undermines topical human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) efficacy through unknown mechanisms. Here, associations between activated endocervical CD4 + T-cell numbers and higher deoxyadenosine triphosphate (dATP) concentrations suggest that competition for intracellular metabolites within HIV target cells may reduce the efficacy of antiretroviral-based PrEP in women with GI. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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