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The agricultural sector is one of the most vulnerable sectors to the impacts of climate change. Between 2015 and 2018, the Western Cape Province of South Africa experienced a multi-year severe drought. Projections show that the Western Cape is likely to experience hotter and drier conditions, with more frequent droughts. Without appropriate adaptation actions, climate change is likely to increasingly constrain agricultural activities in the province. Commercial farmers represent a considerable population of decision-makers, which are fundamental to climate change adaptation. Understanding farmers' perceptions is important to develop effective policy, support structures, and communications. This study aimed to understand wheat farmers' and apple producers' perceptions of climate change and adaptation in the Western Cape, South Africa, and establish whether the recent drought offered lessons for adaptation. Study methods included the use of an online questionnaire as well as several in-depth interviews with farmers and producers. Results showed that most farmers and producers agree that climate change is real and is caused by human activities. Most farmers and producers in the region are already actively (or intend to start) preparing for climate change (69%). In response to climate change, apple producers view on-farm water management (such as irrigation management and water recycling) as the most important strategy. Wheat farmers strategies are focused on crop management (including cultivar selection and conservation agriculture). Many farmers and producers further agreed that they had learnt from the past 2015–2018 drought. Notably, results showed that farmers and producers who rely a great deal on weather forecasts were more likely to feel that their farm's response was effective. Furthermore, it was found that farmers and producers who felt they learned from the drought were also more likely to be actively preparing for climate risks. It is recommended that investments into climate change adaptation focus on research and development, particularly with regard to cultivar development, irrigation management, tailored weather forecasting, and localised risk assessments. Policy should prioritise the more vulnerable farmers and producers while focusing on integrated risk reduction measures which account for multiple stressors. • Farmers learnt from the 2015–2018 (Day Zero) drought and changed certain practices. • Drought led more farmers to prepare for climate change. • Farmers are adapting regardless of their beliefs of climate change. • Highlight the strength of information and social networks in adaptation planning. [ABSTRACT FROM AUTHOR]

Background: Mounting evidence suggests that mindfulness is positively related to athletic performance and athlete wellbeing. However, few attempts have been made to explore the psychological processes by which mindfulness might impact performance. Objective: To determine whether negative self-appraisal mediates the relationship between dispositional mindfulness and the confidence component of mental toughness among provincial adolescent female hockey players in South Africa. Methods: Provincial adolescent female hockey players (n=486) completed measures of dispositional mindfulness, mental toughness-related confidence and negative self-appraisal. Correlation coefficients were calculated between all variables included in the study. An ordinary least-squares regression analysis was performed to test the indirect effect of negative self-appraisal on the relationship between dispositional mindfulness and confidence. Results: Negative self-appraisal exhibited an indirect effect on the relationship between dispositional mindfulness and the confidence component of mental toughness (β = .06, SE = .0, CI95 = .04, .09). A subsequent Soble test confirmed that negative self-appraisal served as a statistically significant mediator (β = .06, SE = .01, Z = 5.76, p = .001) in the model. Furthermore, 78.3% of the variance in the effect of dispositional mindfulness on the confidence component of mental toughness was accounted for by negative self-appraisal. Conclusion: The effect of dispositional mindfulness on the confidence component of mental toughness among adolescent athletes is mediated by negative self-appraisal. Based on the current findings, dispositional mindfulness may foster confidence by lessening the impact of rigid negative appraisals of one's performance and worth as an athlete. [ABSTRACT FROM AUTHOR]

Abstract: This paper documents the manner in which smallholder farmers in Gladstone, a rural village near the town of Thaba Nchu in the Free State Province of central South Africa, perceive and adapt to long-term changes in climate. Farmers'' perceptions of climate risk and their approaches to adaptation are influenced by socio-economic and political factors. The lack of interest in farming among the youth, the inherent imbalances in land access due to political history, government policies on free water access as well as social grants have created dependency and discouraged the need for adaptation to climate change. Farmers are therefore reliant on regular support even in the face of potential uncertainties about the long-term changes in government policies. Farmers deliberately adapting to climate change are innovative and independent of state support. Rainwater harvesting techniques are the most popular risk management and adaptation strategy used and are externally supported and sustained. The findings of this study indicate that government policies must be informed and guided by the risks and opportunities faced by farmers. In addition, farmers need to make conscious decisions to adapt based on their analysis of livelihood risks. Education and awareness on climate change issues at community, programming and policy levels needs to be prioritised. This must be supported by technological developments such as the rainwater harvesting techniques that are showing potential of greater success among small holder farmers. [Copyright &y& Elsevier]

Abstract: Seasonal water content fluctuation within the effective root zone was monitored during the growing season for a maize-bean intercrop (IMB), sole maize (SM) and sole bean (SB) in Free State Province, Republic of South Africa. Comparisons were undertaken for progressive depths of extraction 0–300mm; 300–600mm and 600–900mm respectively. These enabled the understanding of water extraction behavior of the cropping systems within the different soil layers including the topsoil surface normally influenced by soil surface evaporation. Additive intercrops have been known to conserve water, largely due to the early high leaf area index and the higher total leaf area. In this study, the combined effect of the intercrop components seemed to lower the total water demand by the intercrop compared to the sole crops. During the two seasons (2000/2001 and 2001/2002) the drained upper limit (DUL) and crop lower limits (CLL) were determined. The maize-bean intercrop, sole maize and sole bean had CLL of 141mm/m, 149mm/m and 159mm/m respectively. The DUL was 262mm/m for the site and therefore the potential plant extractable soil water for the cropping systems were: 121mm/m (IMB); 114mm/m (SM) and 103mm/m (SB). Overall, the intercrop did not have significantly different total soil water extraction during both seasons, although it was additive, showing that it had higher water to biomass conversion. [Copyright &y& Elsevier]

Relationships between photosynthetically active radiation (PAR) and solar radiation (SR) and between diffuse radiation and global radiation at Bloemfontein, South Africa were investigated. The ratio of PAR to SR (PAR/SR) has been reported from many places in the northern hemisphere, but there were not many PAR/SR measurements documented from the southern hemisphere, including the study region. Based on the present observations, mean PAR/SR in the region (0.48) was not exceptionally different from other reported data (0.45-0.50). The effects of sky condition on PAR/SR were also investigated and confirmed the previous findings. PAR/SR increased as the clearness index (KT?=?ratio of global to extraterrestrial SR) decreased, as sky conditions varied from clear to cloudy. Thus, PAR/SR can be a simple function of the clearness index (the global PAR model). In this study, PAR/SR was explained by a quadratic function ofKT. For the relationship between diffuse and global radiation, a simple linear threshold diffuse PAR model, as a linear function ofKT, was proposed for the study region using long-term data of diffuse and global SR. Using the previous findings on the relationship between the ratio of diffuse to global SR (KSR) and the ratio of diffuse to global PAR (KPAR), at highKT,KPAR can be estimated as 30% higher thanKSR, while at lowKT KPAR is equivalent toKSR. [ABSTRACT FROM AUTHOR]

• Places the 2015-2017 drought in both a historical and future context. • Wheat regions experienced persistent drought with high spatial-temporal variability. • The drought was severe and could be an early sign of climate change in the area. Between 2015 and 2018, the Western Cape Province of South Africa experienced a multi-year severe drought, which negatively impacted major economic sectors. The province serves as an important producer of wheat in South Africa among other agricultural commodities. This study aims to analyze the 2015-2018 drought and its impacts on wheat production in the winter rainfall region of the Western Cape, South Africa. The central focus is to place the drought in both a historical and future context while emphasising the differences between the two core wheat growing regions. We present an analysis of the drought, as well as climate trends computed from weather data sets (1988–2018) from six weather stations across the two core wheat-growing. We first present a meteorological drought analysis of mean annual and seasonal rainfall and temperatures, subsequently providing an agricultural lens by computing Standardised Precipitation and Evapotranspiration Index (SPEI) accumulated over 12- and 36-month timescales, self-calibrated Palmer Drought Severity Index (sc-PDSI), changes to the start and end of the rainfall season, and their effects on wheat yields. Trend analysis was conducted to determine if drought observations form part of the longer-term trends in the region. Finally, we show how the drought varied spatially across the two regions. Results show that between 1988 and 2018, the wheat growing areas of the Western Cape experienced persistent drought with high spatial-temporal variability. The 2015-2018 drought, however, was the most severe experienced in the 30-year study period at five of the six stations. These results are consistent with conditions that can be expected under future climate change. Moreover, results can be useful for the development of early warning systems since they place the drought in the context of past drought conditions. [ABSTRACT FROM AUTHOR]

Objectives: To assess whether plasma concentrations of the circulating inflammatory proteins Interleukin-6 (IL-6), Vascular Cell Adhesion Molecule-1 (VCAM-1) and C-Reactive Protein (CRP) are increased in women with preeclampsia with end-organ complications, compared with women with preeclampsia without end-organ complications., Study Design: We used samples from a large prospective biobank collection (Preeclampsia Obstetric Adverse Event biobank), and two large, randomized preeclampsia therapeutic treatment trials. All samples were collected in Cape Town, South Africa. The last plasma sample collected prior to birth was analyzed for IL-6, VCAM-1 and CRP concentrations. We categorized cases according to disease severity and compared circulating levels of these analytes. Covariate adjustment was performed., Results: 183 women were included. Compared with women without end-organ complications (n = 119), those with preeclampsia with two or more end-organ complications (n = 15) had a 4.9-fold (95 % CI, 1.81-13.09, p = 0.001) increase in IL-6 and a 1.7-fold (95 % CI, 1.11-2.72, p = 0.012) increase in VCAM-1 plasma concentrations. Comparing women with two or more end-organ complications to those with one end-organ complication (n = 49), plasma concentrations of IL-6 were 3.2-fold (95 % CI, 1.18-8.39, p = 0.018) increased, while there was no statistically significant difference for VCAM-1 (1.2-fold higher, 95 % CI, 0.79-1.91, p = 0.50). Plasma concentrations of CRP did not differ between the groups., Conclusions: Plasma concentrations of IL-6 and VCAM-1, but not CRP, were increased among women with preeclampsia and end-organ complications, compared with women without end-organ complications. IL-6 and VCAM-1 could be drivers of disease in preeclampsia and potentially useful to identify women at high risk of severe disease., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Background: National regulatory agencies of various sizes and maturity levels, including the South African Health Products Regulatory Authority (SAHPRA), have had to revise systems and re-engineer processes in order to adapt to the new regulatory environment and increase the effectiveness of regulatory operations. This study aimed to develop a new regulatory review model for improved regulatory performance, underpinned by the parameters of the World Health Organization Global Benchmarking Tool (WHO GBT) that support strengthening of regulatory systems., Methods: A new enhanced model for regulatory review, was developed based on the key recommendations from 6 studies, previously conducted by the authors, that were identified as fundamental elements in enhancing regulatory performance. The elements selected to define the new regulatory review model were endorsed through the integration of the parameters of the WHO GBT that, when embedded within regulatory systems, support enhanced regulatory performance., Results: Opportunities for improvement in regulatory performance were identified and include quality measures; monitoring and evaluating review times; a risk-based evaluation; transparency and communication; and training and education. An improved model for the South African regulatory review and benefit-risk (BR) assessment supported by quality decision-making was proposed as well as recommendations for the application of risk-stratification strategies, strengthening of reliance networks, reinforcing good regulatory practices (GRPs) and enhancing transparency., Conclusion: If implemented the proposed improved regulatory model may pave the way towards more efficient and transparent, streamlined review processes, coupled with increased consistency, evidence-based decision-making practices, reduced timelines and improved patients' access to new medicines in South Africa., (© 2022 The Author(s); Published by Kerman University of Medical Sciences This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.)

Background: This study sought to identify criteria and current practices for implementing an abridged review process and understanding barriers and enablers in utilizing reliance models and to offer recommendations for the implementation of an abridged review process in South Africa based on good reliance practices (GRelP)., Methods: A questionnaire was completed by six national regulatory authorities (NRAs) to determine criteria and current practices for implementing an abridged review process. In addition, two focus group discussions were conducted on the practical implementation of an abridged review process based on GRelP., Results: Participating NRAs indicated that reliance would be placed on one reference agency. Applications submitted to NRAs for an abridged review had to be identical to those submitted to the reference agency. Unredacted reference agency assessment reports would be required to facilitate the abridged review process. A full technical dossier would also be required, but only parts would be assessed during the abridged review. Focus groups indicated that abridged review elements had been identified and should be considered in implementing GRelP., Conclusions: NRAs strive to improve regulatory performance and accelerate approval times; however, many continue to face challenges due to resource constraints. Increasing workloads, advancing technologies, and limited expertise require NRAs to leverage regulatory convergence initiatives, collaborative registration procedures, and functional regional, continental and international networks to fulfil regulatory mandates. Recommendations for the implementation of an abridged review process and a framework for GRelP have been made with a view to optimise regulatory review processes in South Africa.

Background: Timely access to new medicines may be addressed through strengthening of registration efficiencies and timelines by establishing and refining value-added registration processes, resources, and systems. The aims of this study were to evaluate the timelines of the milestones of the South African review process and the overall approval process for new active substances (NASs) in 2015-2018 and to provide recommendations for improved patients' access to new medicines through timely registration., Methods: Data identifying the milestones and overall approval times for NASs registered by the South African Agency during 2015-2018 were collected and analyzed., Results: The most NASs (42) were approved in 2017 and the least (15) in 2018. The shortest median approval time (1218 calendar days) was achieved in 2015 and the longest (2124 days), in 2018. All applications were reviewed using the full review process, and 16/99 (16%) were assigned priority status and were reviewed and approved through the fast track review., Conclusions: While the extensive delays in NASs approvals in South Africa may be attributed to inefficient operational processes, resource constraints, and as an increased number of applications for registration, the newly established South African Heath Products Regulatory Agency has re-engineered and streamlined its regulatory review process, which has been piloted and will be enhanced prior to final implementation. Among recommendations for improvement, SAHPRA should consider measurement and monitoring of milestones, facilitated regulatory pathways, implementing a reliance strategy, and a quality management system.

Background: The aims of this study were to assess the regulatory review process in South Africa from 2015 to 2017, identify the key milestones and timelines; evaluate the effectiveness of measures to ensure consistency, transparency, timeliness, and predictability in the review process; and to provide recommendations for enhanced regulatory practices., Methods: A questionnaire was completed by the Medicines Control Council (MCC) to describe the organization of the authority, record key milestones and timelines in the review process and to identify good review practices (GRevPs)., Results: Currently, the MCC conducts a full assessment of quality, efficacy, and safety data in the review of all applications. The overall regulatory median approval time decreased by 14% in 2017 (1411 calendar days) compared with that of 2016, despite the 27% increase in the number of applications. However, the MCC has no target for overall approval time of new active substance applications and no targets for key review milestones. Guidelines, standard operating procedures, and review templates are in place, while the formal implementation of GRevPs and the application of an electronic document management system are planned for the near future., Conclusions: As the MCC transitions to the newly established South Africa Health Products Regulatory Authority, it would be crucial for the authority to recognize the opportunities for an enhanced regulatory review and should consider models such as abridged assessment, which encompass elements of risk stratification and reliance. It is hoped that resource constraints may then be alleviated and capacity developed to meet target timelines.