1. The utility of 68ga-dotatate pet/ct in localizing primary/metastatic pheochromocytoma and paraganglioma: Asian Indian experience.
- Author
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Jaiswal, Sanjeet, Sarathi, Vijaya, Malhotra, Gaurav, Verma, Priyanka, Hira, Priya, Badhe, Padma, Memon, Saba, Barnabas, Rohit, Patil, Virendra, Anurag, Lila, R, Shah, Nalini, and Bandgar, Tushar
- Subjects
INDIANS (Asians) ,POSITRON emission tomography computed tomography ,PARAGANGLIOMA ,PHEOCHROMOCYTOMA ,PETS ,METASTASIS - Abstract
Purpose: Pheochromocytoma and paraganglioma (PGL), together called PPGL, are rare tumors with a limited number of studies on the diagnostic performance of
68 Ga-DOTA (0)-Tyr (3)-octreotate positron emission tomography-computed tomography (68 Ga-DOTATATE PET/CT) from the Asian-Indian subcontinent. Materials and Methods: In this retrospective study, PPGL suspects (n = 87) who had undergone at least contrast-enhanced computed tomography (CECT) and68 Ga-DOTATATE PET/CT, were included. Lesion-wise, patient-wise, and region-wise sensitivities of68 Ga-DOTATATE PET/CT,18 F fluorodeoxyglucose positron emission tomography CT (18 F-FDG PET/CT, n = 53),131 I-metaiodobenzylguanidine (131 I-MIBG, n = 37), and CECT were compared, and diagnostic performance of68 Ga-DOTATATE PET/CT in the detection of PPGL was calculated. Results:68 Ga-DOTATATE PET/CT had significantly higher lesion-wise sensitivity than131 I-MIBG for both primary (94% vs 75%, P = 0.004) and metastatic disease (85% vs 59%, P = 0.001) and higher sensitivity than CECT for metastatic lesions (83% vs 43%, P = 0.0001). The lesion-wise sensitivity of68 Ga-DOTATATE PET/CT was similar to18 F-FDG PET/CT for both primary tumors (94% vs 85%, P = 0.08) and metastatic lesions (82% vs 84%, P = 0.76) in the whole cohort but tended to be inferior in the head to head comparison. Conclusion:68 Ga-DOTATATE PET/CT had higher sensitivity for detection of PPGL than131 I-MIBG (primary and metastatic) and CECT (metastatic) but similar to18 F-FDG PET/CT (primary and metastatic). [ABSTRACT FROM AUTHOR]- Published
- 2021
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