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BACKGROUD: The control of hip and ankle joint movement is important for patients with dynamic knee valgus (DKV), but few studies have used non-elastic taping (NET) to adjust alignment of the hip and ankle joints during overhead squat (OHS) simultaneously in patients with DKV. OBJECTIVE: We investigated changes in lower extremity joint kinematics and dynamic balance after the application of NET to the hip and ankle joints during OHS. METHODS: A total of 30 DKV patients participated in this study. We determined the kinematics of the hip, knee, and ankle joints, and scores on the lower quarter Y-balance test (YBT-LQ) during OHS under three conditions (non-taping, NET on hip and ankle, and sham taping). RESULTS: Hip internal rotation, knee valgus, and the ankle dorsiflexion angle were significantly lower with NET than with non- or sham taping. The hip flexion angle and scores on the YBT-LQ were significantly greater with NET than with non- or sham taping. CONCLUSIONS: The application of NET while performing a OHS is a useful method for correcting lower extremity alignment in patients with DKV, however, application of NET on the ankle should be considered. [ABSTRACT FROM AUTHOR]

• Elderly patients in urology receive potentially inappropriate medications (PIMs). • 73.7% of patients with lower urinary tract symptoms received PIMs at least once. • The average number of PIMs used per patient was 1.31 ± 1.25 (0–7). • Number of chronic diseases and polypharmacy were predictive factors for PIMs. To investigate polypharmacy and potentially inappropriate medications (PIMs) in elderly patients visiting the urology department for lower urinary tract symptoms (LUTS). We retrospectively analyzed digital medical records of individuals over the age of 65 who visited the urology department for LUTS. This cross-sectional study was conducted in 10 hospitals located in South Korea, between September 2017 and December 2017. All prescribed medications were analyzed using electronic medical records. The updated 2015 Beers criteria were used to identify and assess the appropriateness of the prescribed drugs in elderly patients. We analyzed a total of 2143 patients aged over 65 years from 10 institutions. The mean age was 74.2 ± 6.26 years (65–97), 1634 (76.2%) were men. Patients took a mean of 6.48 ± 2.46 medications (range 0–18), and polypharmacy was found in 1762 patients (82.2%). The number of patients who received PIMs at least once was 1579 (73.7%). The average number of PIMs used per patient was 1.31 ± 1.25 (0–7). PIM use ratio was 18.9 ± 0.15% (0–67%). The number of chronic diseases, and concurrent medication and polypharmacy were predictive factors associated with PIM use. Our multi-institutional results show that a substantial proportion of elderly patients took PIMs when visiting the urology department. Factors associated with PIMs were the number of chronic diseases and polypharmacy. Medication use in elderly patients, especially in urology, should be monitored carefully. [ABSTRACT FROM AUTHOR]

In South Korea, pig-to-nonhuman primate trials of solid organs have only been performed recently, and the results are not sufficiently satisfactory to initiate clinical trials. Since November 2011, we have performed 30 kidney pig-to-nonhuman primate xenotransplantations at Konkuk University Hospital. Donor αGal-knockout–based transgenic pigs were obtained from 3 institutes. The knock-in genes were CD39, CD46, CD55, CD73 , and thrombomodulin , and 2-4 transgenic modifications with GTKO were done. The recipient animal was the cynomolgus monkey. We used the immunosuppressants anti-CD154, rituximab, anti–thymocyte globulin, tacrolimus, mycophenolate mofetil, and steroids. The mean survival duration of the recipients was 39 days. Except for a few cases for which survival durations were <2 days because of technical failure, 24 grafts survived for >7 days, with an average survival duration of 50 days. Long-term survival was observed 115 days after the removal of the contralateral kidney, which is currently the longest-recorded graft survival in Korea. We confirmed functioning grafts for the surviving transplanted kidneys after the second-look operation, and no signs of hyperacute rejection were observed. Although our survival results are relatively poor, they are the best-recorded results in South Korea, and the ongoing results are improving. With the support of government funds and the volunteering activities of clinical experts, we aim to further improve our experiments and contribute to the commencement of clinical trials of kidney xenotransplantation in Korea. [ABSTRACT FROM AUTHOR]