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Polypharmacy and its rising global prevalence is a growing public health burden. Using a large representative nationwide Korean cohort (N = 761,145), we conducted a retrospective cross-sectional study aiming to identify subpopulations of patients with polypharmacy and characterize their unique patterns through cluster analysis. Patients aged ≥ 30 years who were prescribed at least one medication between 2014 and 2018 were included in our study. Six clusters were identified: cluster 1 mostly included patients who were hospitalized for a long time (4.3 ± 5.3 days); cluster 2 consisted of patients with disabilities (100.0%) and had the highest mean number of prescription drugs (7.7 ± 2.8 medications); cluster 3 was a group of low-income patients (99.9%); cluster 4 was a group of high-income patients (80.2%) who frequently (46.4 ± 25.9 days) visited hospitals/clinics (7.3 ± 2.7 places); cluster 5 was mostly elderly (74.9 ± 9.8 years) females (80.3%); and cluster 6 comprised mostly middle-aged (56.4 ± 1.5 years) males (88.6%) (all P < 0.001). Patients in clusters 1–5 had more prescribed medications and outpatient visit days than those in cluster 6 (all P < 0.001). Given limited health care resources, individuals with any of the identified phenotypes may be preferential candidates for participation in intervention programs for optimal medication use. [ABSTRACT FROM AUTHOR]

Objective: To investigate the bilateral concurrence and relationships between distolingual (DL) roots and DL canals of the mandibular first molars and second mesiobuccal (MB2) canals of the maxillary first molars using cone-beam computed tomography (CBCT). Methods: A total of 150 CBCT images showing all mandibular and maxillary first molars were retrospectively investigated in a South Korean subpopulation. The patient age, sex, positions of first molars, and presence of roots and canals were assessed. The frequency, bilateral concurrence of DL roots, DL canals, and MB2 canals, and concurrent relationship of DL roots or DL canals with MB2 canals were investigated. Data were analyzed using Fisher's exact test and odds ratios from binary logistic regression. Results: The prevalences of DL roots, DL canals, and MB2 canals were 24.7, 42.7, and 56.0 %, respectively, and showed significant bilateral concurrence. A concurrent relationship between DL roots and MB2 canals was not demonstrated, whereas the presence of a DL canal was significantly correlated with the presence of an MB2 canal on the same side. Conclusions: The presence of a DL root of the mandibular first molar, a strong ethnic characteristic, could not predict the presence of an MB2 canal of the maxillary first molar. The correlation between DL canals and MB2 canals on the same side and the significant bilateral concurrence, whether present or absent, of DL roots, DL canals, and MB2 canals can aid clinicians in the prediction of additional canals in the first molars. [ABSTRACT FROM AUTHOR]

Abstract: Introduction: This study aimed to investigate the incidence of cone-beam computed tomography (CBCT) associated with endodontic procedures during 2009 in South Korea and to retrospectively evaluate information from CBCT with large field of view (FOV), which is popular in South Korea. Methods: The Health Insurance Review and Assessment agency, which reviews all medical and dental expenses covered under the Korean National Health Insurance (NHI) system, was queried for data on the nationwide number of CBCTs associated with some treatment procedures. To compare digital periapical radiography and CBCT retrospectively, 470 roots of 257 root canal–infected teeth were enrolled. Results: In total, 13,209 cases of NHI-covered CBCT were performed in South Korea during 2009, excluding cases for implant restoration and orthodontics. In total, 1253 and 95 CBCT cases were combined with root canal length measuring and apicoectomy, respectively. In a retrospective comparison, CBCT with large FOV provided more information about the presence of apical periodontitis, distortion of cortical bone, and identification of root compared with digital periapical radiography. Conclusions: CBCT with large FOV is useful in nonsurgical endodontic treatment and provides more information compared with digital periapical radiography. [Copyright &y& Elsevier]