1. Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking.
- Author
-
Ryu, Byeol, Cho, Hyo Moon, Zhang, Mi, Lee, Ba Wool, Doan, Thi Phuong, Park, Eun Jin, Lee, Hee Ju, and Oh, Won Keun
- Subjects
- *
GUAVA , *RACEMIC mixtures , *PHOSPHOPROTEIN phosphatases , *PLANT variation , *MOLECULAR docking , *CIRCULAR dichroism - Abstract
MS/MS-based molecular networking showed differences in the chemical profiles, especially the terpenoid-coupled-phloroglucinol clusters, of Psidium guajava grown in Jeju Island of South Korea ("Jejuguava"), Vietnam and China. A chemical investigation of the 95% EtOH extract of Jejuguava leaves revealed meroterpenoids characterized by a dihydropyran ring junction between an acylphloroglucinol structure and terpenoid, and named jejuguajavones A–J (1 – 10). Compounds (±)- 8 –(±)- 10 are racemic mixtures that were separated using a chiral HPLC column. The chemical structures of all the isolated compounds (1 – 10) were determined by analyzing the spectroscopic data and performing electronic circular dichroism calculations. Among the isolates, compounds 1 – 4 exhibit inhibitory activity against the protein tyrosine phosphatase 1B (PTP1B) enzyme, and this result was confirmed by molecular docking simulations. [Display omitted] • Ten Psidium meroterpenoids were isolated from P. guajava grown in Jeju Island, Korea. • PTP1B inhibitory activity of all isolates and molecular docking were analysed. • Ecological and adaptive variations in plants also affect their chemical composition. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF