1. Pregnancy outcomes in women reporting ingestion of levosulpiride in early pregnancy.
- Author
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Shin, You Jung, Choi, June Seek, Ahn, Hyun Kyong, Ryu, Hyun Mee, Kim, Moon Young, and Han, Jung Yeol
- Subjects
TERATOGENIC agents ,PREGNANCY complications ,TERATOGENESIS ,MISCARRIAGE ,PREGNANT women ,HUMAN abnormalities ,BENZAMIDE ,GESTATIONAL age ,LONGITUDINAL method ,EVALUATION of medical care ,PREGNANCY ,FIRST trimester of pregnancy ,DRUG-induced abnormalities ,MATERNAL exposure - Abstract
This study aimed to evaluate pregnancy outcomes of women who were inadvertently exposed to levosulpiride in early pregnancy. All 162 consecutive singleton pregnant women counselled through the Korean Motherisk Program, Cheil General Hospital, between April 2001 and April 2014, on teratogenic risk after inadvertent exposure to levosulpiride in early pregnancy were enrolled in this study. The women were exposed to levosulpiride at median 4.8 gestational weeks. The rate of miscarriage was not significantly different between groups (9.2% in those exposed and 5.5% in the non-exposed; p = .084). The rate of major malformations was not significantly different between exposed (2.7%) and non-exposed pregnancies (4.4%) (p = .481). All other pregnancy outcomes between the two groups were comparable (p > .05). Our data suggest that levosulpiride causes no significant adverse effects on pregnancy outcomes and therefore may be not a major teratogen. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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