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Cercarial production related to miracidial dose variation with Schistosoma bovis strains from Sudan and Spain in Bulinus truncatus from Tunisia was studied. Results showed that an increase in the miracidial dose proposed to the host-mollusc (1 and 5 miracidia) gave rise to a decrease in cercarial productivity of Sudanese S. bovis and to an increase for Spanish S. bovis. It is concluded that this response difference to the miracidial dose variation depends on genetic characters peculiar to the parasite strain and represents a new aspect of genetic variability of schistosome populations.