1. Controversies in the therapeutic approach to congenital cytomegalovirus infection.
- Author
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Garrido-Barbero M, Arnaez J, and Garcia-Alix A
- Subjects
- Antiviral Agents therapeutic use, Cytomegalovirus physiology, Cytomegalovirus Infections congenital, Cytomegalovirus Infections diagnostic imaging, Cytomegalovirus Infections drug therapy, Female, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Spain, Valganciclovir therapeutic use, Brain diagnostic imaging, Cytomegalovirus Infections diagnosis, beta 2-Microglobulin cerebrospinal fluid
- Abstract
Treatment of congenital cytomegalovirus infection is mandatory in cases with severe systemic and/or neurological involvement. However, some patients are paucisymptomatic, with very subtle systemic manifestations and/or minimal brain alterations. Current international guidelines do not clearly state whether these children should be treated, and this decision is not straightforward for clinicians. Of a small series of six infants with congenital cytomegalovirus infection admitted to our neonatal unit between 2015 and 2019, half showed paucisymptomatic neurological manifestations. In these cases, the determination of ß2-microglobulin in cerebrospinal fluid and magnetic resonance imaging aided in the decision-making concerning the therapeutic approach to follow.
- Published
- 2020
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