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Background and Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by challenges in communication, social interactions, and repetitive behaviors. Although the factors that influence the development of this condition are unknown, certain chemical compounds such as pesticides have been proposed as possible contributors. Due to the lack of an established causal link between pesticide exposure and ASD, this study aimed to evaluate this potential association. Materials and Methods: A case-control study was carried out to ascertain the prevalence and risk associated with ASD in relation to pesticide exposure over a 21-year study period (2000–2021). Results: We included 2821 individuals diagnosed with ASD residing in areas of both high and low pesticide exposure in southern Spain. There was a rise in the ASD prevalence rate in regions with elevated pesticide use when compared to regions with low use [odds ratio (OR): 1.34, 95% confidence interval (CI), (1.24–1.44)]. Notably, men had the highest likelihood, with an OR: 1.42, 95% CI, (1.30–1.55). Furthermore, after performing multiple binary logistic regression adjusted for age, sex, and geographical area, males exhibited a higher likelihood compared to females [OR: 2.41, 95% CI, (2.21–2.62)]. Conclusions: Overall, this research suggests a connection between heightened environmental pesticide exposure due to increased agricultural use and autism. [ABSTRACT FROM AUTHOR]

Mercury (Hg) is a toxic metal that can cause adverse effects for the health of ecosystems. The Caudal River is one of the main rivers in the Asturias region (NW Spain), whose basin is highly anthropized, hosting several Hg mines, closed in the last century. Arsenic (As) is also found in the mineral paragenesis of the Hg deposits, posing a greater environmental risk. In the mining sites, remaining old facilities and tailings continue to release these elements into the environment. In this work, samples of fluvial sediments and water were taken, both in areas affected by anthropic activity and in pristine areas, in order to establish the background levels for the critical elements. The mineralogical study of the sediments, combined with EDS microanalysis, is useful to identify mineralogical traps such as Fe oxides or clays to retain the As. The As content in all sampled sediments is above the threshold effect levels (TEL), the possible effect range within which adverse effects occasionally occur, according to the Canadian Sediment Quality Guidelines for the Protection of Aquatic Life. This fact is related to a naturally high geochemical background in the basin, due to the existing mineral deposits. The PEL threshold (the probable effect range within which adverse effects frequently occur) is exceeded by more than an order of magnitude in the sediments downstream of the Hg mines. In these points, the As content in the water, exceeding 700 μg L−1 As, is also above the quality standard established in Spanish legislation. As a result, the Caudal River tributaries in the lower part of the basin do not reach a good ecological state, according to the Hydrological Planning Office, and in some cases their state is deficient, showing low richness and high dominance of macroinvertebrates. Although the concentrations decrease with distance from the source, these findings justify the low ecological quality of the affected watercourses. [ABSTRACT FROM AUTHOR]

The "Art-Risk 3.0" research project has developed a new tool to address the challenges faced in maintaining and preserving cultural heritage. This tool aims to evaluate the functional operational age and life cycle of heritage buildings in the Arc de Berà area in Tarragona, Catalonia, Spain, with the goal of promoting preventive conservation through a multidisciplinary approach. The tool considers various factors that contribute to the condition of heritage buildings, including structural stability, material decay, environmental risks, and usage patterns. By employing a fuzzy model, it provides an assessment of the building's condition in historical sites. One of the key features of the Art-Risk tool is its ability to prioritize intervention among different case studies within a specific urban context. It generates three output results: vulnerability, risk, and functionality index. The vulnerability value indicates the level of vulnerability of a building, with lower values suggesting better structural stability and resilience against potential hazards. The risk value signifies the level of risk associated with a building, with lower values indicating a reduced likelihood of damage or deterioration. The functionality index reflects the operational condition and suitability of a building for its intended use, with higher values indicating better functionality and operational performance, by considering these diverse valuations, stakeholders and conservation plan managers can effectively establish priorities for intervention. Buildings with higher vulnerability, risk, or lower functionality index scores are given higher priority for intervention. This approach ensures that limited resources are allocated to the buildings that require immediate attention, maximizing the impact of conservation efforts. Art-Risk3.0 model incorporates 19 input variables, with five variables automatically assigned based on the building's geographic location. Users are required to provide valid geographical coordinates and the remaining 14 associated values to obtain an accurate assessment of the building's condition. [ABSTRACT FROM AUTHOR]

The Spanish government has made concerted efforts to simplify environmental assessment processes. In the case of the 'simplified' Strategic Environmental Assessment approach, this has been done with the objective of streamlining processes and resources, so that plans and programmes, or their modifications, that are considered to potentially have insignificant or negligible environmental effects are not subject to a full assessment. In contrast, the recently introduced 'environmental effects determination procedure' for renewable projects has the purpose of speeding up project approval processes in response to energy security challenges with a resulting potential risk of weakening assessment procedures and debilitating environmental protection. Simplification attempts should not only comply with legal mandates but proactively foster environmentally-sound, participatory and transparent decisions. [ABSTRACT FROM AUTHOR]

The occurrence of emerging micropollutants (pharmaceuticals, pesticides, personal care products, industrial compounds, etc.) in the environment is considered a major threat to human health and aquatic ecosystems. These micropollutants enter the environment through anthropogenic actions and have been identified in surface, ground, waste, and even in drinking water, in quantities ranging from ng L−1 to µg L−1. Currently, the pollution of the global water cycle with persistent organic pollutants remains one of the major challenges of the twenty-first century. Most of these organic substances are only partially removed by conventional wastewater treatment plants. Particularly, considerable amounts of pharmaceuticals are used in human and veterinary medicine, which are not efficiently removed during conventional wastewater treatments and subsequently continuously enter freshwater systems and even agricultural crops. Accordingly, we have evaluated the effectivity of TiO2 as a photocatalyst in tandem with Na2S2O8 as an oxidant for the treatment of a wastewater effluent polluted with pharmaceutical (atenolol, carbamazepine, clarithromycin, erythromycin, irbesartan, and ketoprofen) residues. Results show that the use of solar heterogeneous photocatalysis by means of band-gap semiconductor materials, especially TiO2 in combination with a strong oxidant such as Na2S2O8, significantly enhances their disappearance from the wastewater effluent. However, the selected pharmaceuticals show a slow degradation in wastewater effluent compared to pure water indicating that the occurrence of dissolved salts and organic carbon in wastewater effluent noticeably slows down the efficiency of the treatment. A single first-order model satisfactorily explains the photocatalytic degradation of the compounds studied for both, pure and wastewater. In the case of wastewater effluent, the highest DT50 values were observed for macrolides (13 and 16 min for erythromycin and clarithromycin, respectively), while the other compounds studied showed DT50 values below 10 min. This methodology has a notorious interest in some areas of the Mediterranean basin with water shortage, such as SE of Spain, where more than 3000 h of sunlight per year are recovered. [ABSTRACT FROM AUTHOR]

Purpose: This paper explores the operationalization of production network coordination – the production transfer (PT) – and the relationships between transfer risk sources, preventive actions, supply chain disruptions, corrective actions and losses to better understand how to mitigate the risk and achieve an effective transfer process. Design/methodology/approach: A longitudinal field study of a PT process from Norway to Spain was studied in depth for 25 months. Findings: The paper presents the implications of three areas of importance for PT success: (1) how the transfer influences the plant roles, (2) the cross-locational management of the transfer project at the sender and receiver and (3) whether adapting the transferred production to the receiver's environment is an enabler or an inhibitor of transfer success. Practical implications: The findings about how to mitigate the transfer risk and the frameworks of risk sources, supply chain disruptions, losses and preventive and corrective actions, along with the examples from the in-depth study, can aid the practitioners in managing PTs and achieving the relocation goals. Originality/value: This is one of the first studies of PT, which is from the perspective of both transfer parties, and addresses both preventive and corrective actions and all the transfer phases. Moreover, this study addresses the operational aspects of production network coordination, which received limited attention in earlier research. [ABSTRACT FROM AUTHOR]

Besides the benefits of plant protection products (PPPs) for agricultural production, there is an increasing acknowledgement of the associated potential environmental risks. Here, we examine the feasibility of summarizing the extent of PPP usage at the country level, using Ireland as a case study, as well as at the European level. We used the area over which PPPs are applied (basic area) as an example variable that is relevant to initially assess the geographic extent of environmental risk. In Irish agricultural systems, which are primarily grass-based, herbicides fluroxypyr and glyphosate are the most widely applied active substances (ASs) in terms of basic area, followed by the fungicides chlorothalonil and prothioconazole that are closely associated with arable crops. Although all EU countries are subject to Regulation (EC) No 1185/2009, which sets the obligation of PPP usage data reporting at the national level, we only found usable data that met our criteria for Estonia, Germany, Finland, and Spain (4 of 30 countries reviewed). Overall, the most widely applied fungicide and herbicide in terms of basic area were prothioconazole (20%, 7% and 5% of national cultivated areas of Germany, Estonia and Ireland) and glyphosate (11%, 8% and 5% of national cultivated areas of Spain, Estonia and Ireland) respectively, although evaluations using application frequency may result in the observation of different trends. Several recommendations are proposed to tackle current data gaps and deficiencies in accessibility and usability of pesticide usage data across the EU in order to better inform environmental risk assessment and promote evidence-based policymaking. [ABSTRACT FROM AUTHOR]

Soil and water characteristics and biogeochemical processes can be improved by the application of an integrated technology based on circular economy: designed Technosol. The evaluation of the effectiveness of the superficial application of a designed Technosol, with andic and eutrophic properties, on the rehabilitation of sulfide tailings of a uranium mine (Fé mining area, Spain) was the aim of this study. After 20 months of the Technosol application, the tailing rehabilitation status (Rehabilitated tailing) was compared to a non-rehabilitated tailing (Tailing). To assess the rehabilitation of these systems, several properties were analyzed: chemical characteristics of the materials and their leachates, soil enzymatic activities (dehydrogenase, β-glucosidase, acid phosphatase and urease), basal respiration and several plant endpoints from direct and indirect bioassays and pot experiment using Lolium perennse L. and Trifolium pratense L.. Potentially toxic concentrations of Co, Mn and Ni were identified in both available fraction and leachates, pointing out the serious environmental risk posed by the tailing. The improvement of overall physicochemical properties in the rehabilitated tailing materials (e.g., decrease of the hazardous element concentrations in leachates and available fraction, and improvement of the fertility and structure) allowed a quick plant cover with pasture species and provided a suitable habitat for active microbial community (evaluated by increasing dehydrogenase activity and basal respiration). This improvement in the rehabilitated tailing contributed to a significant decrease in the ecotoxicological risk and the spread of hazardous elements. The field application of this specific Technosol was a promising and lasting solution for rehabilitation of this type of tailings. [ABSTRACT FROM AUTHOR]

The pervasive occurrence of emerging contaminants (ECs) in sewage sludge (SWS) poses significant safety challenges concerning the processing, disposal, and secure application, ultimately jeopardizing both human health and the ecological environment. To comprehensively comprehend the evolutionary trajectories, present state, and research advancements in the field of ECs in SWS, a systematic was conducted, scrutinizing the annual publication quantity, disciplinary distribution, core authors, involved nations/regions, pertinent keywords, and citation status of 2082 research publications related to ECs in SWS from 1990 to 2023. The results indicate a substantial upward trajectory in the research literature pertaining to ECs in SWS. The study of ECs in SWS encompasses 78 disciplines, including Environmental Sciences, Environmental Engineering, and Water Resources. China, Spain, and the USA ranked among the top three countries in terms of both total publications and citation frequency. The majority of publications were published in reputable high-impact journals such as Science of the Total Environment , Chemosphere , and Bioresource Technology. Based on high-frequency keywords, co-occurrence networks of keywords, and keywords burst analysis, it is found that the occurrence and environment behavior of ECs in SWS (ARGs, microplastics, PPCPs, and POPs), the detection and analytical methods, the impact on SWS treatment and disposal processes, and the accumulation and ecological risks in plants and soil during SWS land utilization, are the main research directions and hot topics in this field. In the future, the study of the impact of SWS treatment technologies on ECs removal is expected to receive increased research attention. [Display omitted] • A bibliometric analysis of emerging contaminants (ECs) in sewage sludge (SWS) was conducted. • The prominent research groups and journals were revealed. • ARGs and POPs were the research focus on ECs in SWS. • Future directions and corresponding challenges were provided. [ABSTRACT FROM AUTHOR]

The conservation of submerged vegetation is crucial in the functioning of aquatic ecosystems. We have assessed, by means of subaquatic quantitative sampling transects, the current status of the hydrophytic flora in 14 lakes in the Lagunas de Ruidera Natural Park, a Biosphere Reserve site in central Spain, surrounded by a semi-arid landscape. The conforming lakes have endured several anthropic pressures for decades (e.g., eutrophication, land-use changes, etc.). By comparing the current with the former status (20 years ago) of hydrophytes in the natural park, substantial negative (species richness loss, decrease in submerged meadow coverage, particularly in the upstream lakes) and positive (natural recovery of meadows after the cut-off of sudden disturbances caused by point pollution sources, improving of trophic state in some lakes, no presence of exotic hydrophytes) changes in the lakes were noticed. We have analyzed that the disappearance of all the hydrophyte (mainly charophytes) stands would represent the loss of ecosystem services. For example, up to 70 t CH 4 might be released from the charophyte detritus, an internal pool of phosphorus (as high as 1400 mgP/m2) stored in the charophytes stands could be liberated. Some lakes require special measures, but overall, to preserve this lake complex, and other similar ones, we propose to study, in detail, the causes of submerged vegetation deterioration (focusing on the presence of pesticides –in water and sediments-, and other reasons) to assess the ecological risks, to protect the groundwater resources, preventing the lakes from receiving surficial point and non-point sources of pollution. [ABSTRACT FROM AUTHOR]

The European Medicines Agency (EMA) mandates Environmental Risk Assessments (ERAs) since 2006 to determine potential risks of new marketed medicines. Drugs with a Predicted Environmental Concentration (PEC) in inland surface waters exceeding 0.01 μg L−1 require further environmental risk assessment. PEC may be refined based on prevalence data and/or based on the treatment regimen. In this study, based on EMA regulations, refined PEC of 108 antineoplastic drugs in coastal waters were determined based on the consumption in a coastal health area during 2021, identifying six drugs with potential environmental risk in surface waters (hydroxyurea, capecitabine, abiraterone, ibrutinib, imatinib and 5-fluorouracil) and two in marine ecosystem (hydroxyurea and capecitabine). Comparison of these refined PECs with data from marketing laboratories revealed significant disparities, suggesting the need for regular updates, especially with changes in drug indications or financing. Notably, the identified drugs are not yet on the main reference lists of emerging contaminants. [Display omitted] • During the year 2021, a Spanish third level hospital used 108 antineoplastic drugs. • 6 antineoplastics may carry environmental risk in surface waters in our study area. • Hydroxyurea and capecitabine may cause risk in the marine environment. • The most consumed drugs are not included in the OSPAR and NORMAN lists. • Real drug consumption data is necessary to assess the potential environmental risk. [ABSTRACT FROM AUTHOR]

Mapping methods to represent the interplay between environmental changes and prehistoric communities were investigated through a case study of the Mediterranean Iberia coastal landscape in the context of Holocene sea-level rise. We developed a four-dimension GIS-based analysis of the environmental evolution based on primary data acquisition (fieldwork, laboratory analyses) and spatial modeling of paleo-Digital Elevation Models (paleoDEMs). Five paleoDEMs were computed, representing key stages of the morphogenetic evolution between 9000 and 7000 years ago. Second, each paleoDEM was used as input in a Site-Catchment Analysis (a 1- and 2-hour walking distance from the archeological sites). Finally, we provide a bird-view visualization of the landscape evolution, centered on the perspective of an individual located at the archeological sites. By shifting the focus to the human scale, this GIS-assisted mapping allows refining assessments of the impact of environmental changes on settlement and subsistence patterns during the Mesolithic and Early Neolithic periods. [ABSTRACT FROM AUTHOR]

As a result of climate change, water-related disasters have increased in the last decade. In the month of October 2018, in the town of Sant Llorenç (Mallorca, Illes Balears, Spain), torrential rains occurred that caused the overflow of the stream that passes through the municipality, causing personal and material damages (including death). In this research, it is intended to develop a characterization of the damage produced in the middle term (seven months after the natural hazard), through the analysis of hygrothermal conditions, humidity in walls, and indoor air quality in seven houses and in one corner shop. The most used or habitable rooms are selected, analyzing a total of twenty-one rooms. The UNE 171330-2-2014 standard is considered for the determination of environmental risks for the occupants' health. The results obtained show that the users are aware of the need of ventilating the spaces, but, although hygrothermal comfort conditions and indoor air quality are within acceptable ranges, the rising damp highest level is high, since it even exceeds 2 m high in three of the twenty-one rooms assessed. The importance of diagnosing the effects of damage and the vulnerability of buildings in the event of a natural disaster is shown. [ABSTRACT FROM AUTHOR]

Under current Spanish law, domestic use of recycled water is only permitted during an officially declared disaster; however, it could be an option from a regulatory perspective. However, would Spaniards be willing to use recycled water in the home if necessary? This study investigates the public acceptance of recycled water use in Spanish households and identifies the determinants of acceptance. In data from 791 questionnaires administered in southern Spain, recycled water is the least acceptable option for alternative sources of water, behind both rainwater collection and desalination. Perceived health risk and environmental awareness explain the differences in acceptance. [ABSTRACT FROM AUTHOR]

Background and objective: The relationship between IPF development and environmental factors has not been completely elucidated. Analysing geographic regions of idiopathic pulmonary fibrosis (IPF) cases could help identify those areas with higher aggregation and investigate potential triggers. We hypothesize that cross‐analysing location of IPF cases and areas of consistently high air pollution concentration could lead to recognition of environmental risk factors for IPF development. Methods: This retrospective study analysed epidemiological and clinical data from 503 patients registered in the Observatory IPF.cat from January 2017 to June 2019. Incident and prevalent IPF cases from the Catalan region of Spain were graphed based on their postal address. We generated maps of the most relevant air pollutant PM2.5 from the last 10 years using data from the CALIOPE air quality forecast system and observational data. Results: In 2018, the prevalence of IPF differed across provinces; from 8.1 cases per 100 000 habitants in Barcelona to 2.0 cases per 100 000 in Girona. The ratio of IPF was higher in some areas. Mapping PM2.5 levels illustrated that certain areas with more industry, traffic and shipping maintained markedly higher PM2.5 concentrations. Most of these locations correlated with higher aggregation of IPF cases. Compared with other risk factors, PM2.5 exposure was the most frequent. Conclusion: In this retrospective study, prevalence of IPF is higher in areas of elevated PM2.5 concentration. Prospective studies with targeted pollution mapping need to be done in specific geographies to compile a broader profile of environmental factors involved in the development of pulmonary fibrosis. [ABSTRACT FROM AUTHOR]

The presence of pharmaceutical compounds in the whole environment is a growing concern. These compounds might be present in the effluents of wastewater treatment plants and, hence, irrigation with treated sewage may be a source of groundwater pollution. The volcanic aquifer that lies NE of Gran Canaria (Spain) was studied to address the relationship of the occurrence of pharmaceutical compounds and a golf course that has been irrigated with regenerated water since 1973. Of the 14 analyzed groundwater samples, five wells were chosen to perform annual monitoring. Irrigation water and soil leachate were also evaluated. The target analytes were atenolol, metamizole, fluoxetine, ibuprofen, nicotine, permethrin, caffeine, and their metabolite paraxanthine. The environmental risk is limited as the concentrations of the pharmaceuticals measured in the sampled wells were always below 60 ng·L−1 (lower than the detected caffeine and nicotine concentrations). Wide variations for the same wells were measured among sampling campaigns, and also among the different wells. The study points to the importance of sample conservation during transport and the need to perform analyses immediately, or to follow an in-situ extraction procedure to carry concentrated samples under better conditions. [ABSTRACT FROM AUTHOR]

Antibiotic residues can reach aquatic ecosystems through urban wastewater discharges, posing an ecotoxicological risk for aquatic organisms and favoring the development of bacterial resistance. To assess the emission rate and hazardousness of these compounds, it is important to carry out periodic chemical monitoring campaigns that provide information regarding the actual performance of wastewater treatment plants (WWTPs) and the potential impact of the treated wastewater in the aquatic environment. In this study, 18 of the most widely consumed antibiotics in Spain were determined by liquid chromatography-tandem mass spectrometry in both influent (IWW) and effluent wastewater (EWW) samples collected over four seasons along 2021–2022. Eleven antibiotics were detected in EWW with azithromycin, ciprofloxacin and levofloxacin showing the highest concentration levels (around 2 μg L−1 of azithromycin and 0.4 μg L−1 of quinolone compounds). Data showed that only 4 out of the 11 compounds were removed by more than 50 % in the WWTP, with sulfamethoxazole standing out with an average removal efficiency >80 %. The risk that treated water could pose to the aquatic environment was also assessed, with 6 compounds indicating a potential environmental risk by exceeding established ecotoxicological and resistance thresholds. Based on the risk assessment, the WWTP removal efficiency required to reduce such risk for antibiotics was estimated. In addition, pooled wastewater samples were screened by LC coupled to high resolution mass spectrometry with ion mobility separation, searching for metabolites and transformation products of the antibiotics investigated to widen future research. Studies like this are crucial to map the impact of antibiotic pollution and to provide the basis for designing water quality and risk prevention monitoring programs. [Display omitted] • Temporal variations were observed for 18 antibiotics present in urban wastewater. • Four metabolites and high concentrations of azithromycin and ciprofloxacin were found in wastewater. • Only 4 antibiotics out of the 11 detected are removed by >50% in the treatment plant. • Six antibiotics show ecotoxicological and/or resistance development risks. • Target removal efficiencies were calculated based on environmental thresholds. [ABSTRACT FROM AUTHOR]

In this study, the presence of 23 pharmaceutically active compounds (PhACs) including antibiotics, analgesics, anti-inflammatories, psychiatric and cardiovascular drugs, antifungals and metabolites was investigated in surface waters. A total of 89 samples were collected during 3 years (2020, 2021 and 2022) from a European representative river basin (Tagus, Spain). To elucidate PhAC potential sources, sampling points located in areas with low, median and high anthropogenic influence were selected. The analytical method based on solid phase extraction (SPE) followed by UHPLC-MS/MS analysis was validated meeting SANTE/2020/12830 and SANTE/12682/2019 performance criteria. PhACs were quantified above limits of quantification (LOQs) in 96 % of water samples, being the antihypertensives valsartan (648 ng/L, 87 % quantification frequency) and irbesartan (390 ng/L, 75 %) and the antidepressant o-desmethylvenlafaxine (495 ng/L, 76 %) the predominant pollutants. The rest of the target PhACs showed median concentrations between 4 and 172 ng/L with quantification frequencies ranging from 35 to 75 %. ∑PhAC concentrations did not show temporal or seasonal trends. However, valsartan and naproxen presented lower levels in drier (spring and summer) compared to the wetter. Source identification revealed a clear anthropogenic origin since concentrations obtained in highly populated areas were statistically higher (p < 0.01) than those quantified in sparsely populated ones. This finding was also confirmed by calculating PhACs mass flow rates, which ranged between 1.4 and 235 kg/y. Finally, data generated were used to estimate the potential risk to the aquatic ecosystem for three trophic levels (phototrophic, invertebrate and vertebrate organisms). Risk quotient ratios (RQs) were calculated for all PhACs at the median (P50) and worst-case (max) scenarios. Up to 7 PhACs (acetaminophen, carbamazepine, gemfibrozil, ibuprofen, irbesartan, ketoprofen and venlafaxine) showed high risk for the highest trophic level (fish) in >45 % of investigated locations., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)

A study of the impact of an abandoned lead (Pb) mine ("Las Musas"), located in SW Spain, on the contamination of the surface soil and pastures in its vicinity revealed the presence of widely distributed, high levels of Pb contamination. The total Pb concentrations in soils sampled at distances from 3 to 998 m from the mine ranged between 129 and 1053 mg/kg, when it has been reported that non-polluted soils have concentrations of 29–40 mg/kg. These exceed the maximum tolerable levels in agricultural soils for the protection of environmental and human health as established in international and regional regulations. While the concentrations of potentially bioavailable Pb in the soils also surpassed the regulatory levels, the effective bioavailable fractions were low. The Pb concentrations measured in native plants ranged from 1.70 to 129 mg/kg dry weight, with Cynosurus echinatus, Philadelphus coronarius, and Fraxinus angustifolia being the species that bioaccumulated the greatest concentrations of this metal. Estimation of the environmental risk to wildlife and livestock grazing in the studied area showed no potential toxicity for these animals. [ABSTRACT FROM AUTHOR]

Purpose: We aim to assess if air pollution levels and climatological factors are associated with hospital admissions for exacerbation of chronic obstructive pulmonary disease (COPD) in Spain from 2004 to 2013. Methods: We conducted a retrospective study. Information on pollution level and climatological factors were obtained from the Spanish Meteorological Agency and hospitalizations from the Spanish hospital discharge database. A case-crossover design was used to identify factors associated with hospitalizations and in hospital mortality. Postal codes were used to assign climatic and pollutant factors to each patient. Results: We detected 162,338 hospital admissions for COPD exacerbation. When seasonal effects were evaluated we observed that hospital admissions and mortality were more frequent in autumn and winter. In addition, we found significant associations of temperature, humidity, ozone (O3), carbon monoxide (CO), particulate matter up to 10 μm in size (PM10) and nitrogen dioxide (NO2) with hospital admissions. Lower temperatures at admission with COPD exacerbation versus 1, 1.5, 2 and 3 weeks prior to hospital admission for COPD exacerbation, were associated with a higher probability of dying in the hospital. Other environmental factors that were related to in-hospital mortality were NO2, O3, PM10 and CO. Conclusions: Epidemiology of hospital admissions by COPD exacerbation was negatively affected by colder climatological factors (seasonality and absolute temperature) and short-term exposure to major air pollution (NO2, O3, CO and PM10). [ABSTRACT FROM AUTHOR]

The study presented here is a first qualitative assessment of the occurrence of organic contaminants contemplated and not yet contemplated in European Union environmental legislation in water resources in the little anthropized Guadiaro River basin (70% of its area is covered by natural vegetation), in southern Spain. Water samples were collected from four carbonate aquifers, two detrital aquifers and four surface water courses and were analyzed for (i) 171 organic contaminants, (ii) major ions and (iii) stable isotopes (δ18O H2O , δ2H H2O , δ13C DIC). An environmental risk assessment was conducted through calculation of risk quotients comparing measured concentrations with ecotoxicological data found in the literature. Twenty-five organic contaminants were detected, at least once, including pesticides, pharmaceuticals, drugs of abuse and polycyclic aromatic hydrocarbons (PAHs). Cocaine and its main metabolite were detected in 85% and 95% of water samples, respectively (0.001–0.18 μg/L and 0.004–0.6 μg/L, respectively). Pyrene (PAH) was found in all water samples (0.001–0.015 μg/L) and forest fires were pointed out as a potential diffuse source. Relationship between rivers and aquifers is reflected by the distribution of organic contaminants, essentially the drugs of abuse. Concentration of contaminants were generally higher in groundwater samples, especially from detrital aquifers, potentially due to an accumulation process promoted by irrigation-return flows and by its slow dynamic compared to that of karstic systems. Pyrene concentration was also higher in some springs from karstic aquifers. Hence, calculated risk quotients were in general higher in groundwater, meaning that the threat to surface aquatic systems can grow as aquifers increase their influence on the water courses as the dry season progresses. The relationship between δ13C DIC and most organic contaminants (especially pyrene) reveal the role of the soil as storage media. [Display omitted] • Fires-derived pyrenes could be considered a continuous pressure in the study area • Relation of contaminants and δ13C in water shows the soil's role as storage media • Detrital aquifers are the major indicators of potentially polluting processes • Distribution CECs is independent of environmental protection in the study area. • Risk quotients (RQ) are a good starting point for environmental risk assessment [ABSTRACT FROM AUTHOR]

Purpose Environmental management (EM) is becoming increasingly important in all types of organizations. The food industry represents the top industrial sector of the Spanish economy; however, there is still little knowledge about how it is managed environmentally. The purpose of this paper is to present a descriptive analysis of the Spanish food sector.Design/methodology/approach This study undertook a descriptive analysis based on probabilistic sampling surveys from food companies in Spain. The survey was sent out to 900 companies obtaining 128 answers.Findings The results of this study show that companies with an EM standard tend to have a more developed system and a greater presence of EM tools and actions. Moreover, statistical differences were identified among the characteristics of companies and various factors that affect the evolution of their EM.Originality/value There are no studies that reveal a clear picture of the status of EM in the Spanish food industry. This study presents a clear starting point that might help policy makers, consultants, researchers and other parties to set new improvement routes so companies do not get stuck in their progress toward environmental excellence. [ABSTRACT FROM AUTHOR]

Oil spills are one of the most widespread problems in port areas (loading/unloading of bulk liquid, fuel supply). Specific environmental risk analysis procedures for diffuse oil sources that are based on the evolution of oil in the marine environment are needed. Diffuse sources such as oil spills usually present a lack of information, which makes the use of numerical models an arduous and occasionally impossible task. For that reason, a tool that can assess the risk of oil spills in near-shore areas by using Geographical Information System (GIS) is presented. The SPILL Tool provides immediate results by automating the process without miscalculation errors. The tool was developed using the Python and ArcGIS scripting library to build a non-ambiguous geoprocessing workflow. The SPILL Tool was implemented for oil facilities at Tarragona Harbor (NE Spain) and validated showing a satisfactory correspondence (around 0.60 RSR error index) with the results obtained using a 2D calibrated oil transport numerical model. [ABSTRACT FROM AUTHOR]

We statistically analysed the chemical components present in waste water from mines in Galicia (NW Spain). These elements pose a risk to public health and the environment, most particularly in the event of a failure in the containment structure of a pond or dam. The statistical processing of the data, which started with an analysis of the typical contaminants present in mining ponds and dams, pointed to the potential limitations of using non-spatial models for spatially structured data. Our results indicate the greater potential of the generalized linear spatial model over the generalized linear model for analysis of spatially structured data. We also show how a misspecification of the model for analysing spatial data can lead to misleading conclusions, which might lead, in turn, to poorly designed protective or corrective measures. [ABSTRACT FROM AUTHOR]

Ground movements constitute active processes that modify the disposition and morphology of the earth's surface. This work establishes a cartography procedure to obtain a ground movement risk map at a 1:50,000 scale. Such a map would be useful for establishing mitigation measures for land use planning and management in natural spaces, using Geographic Information Systems (GIS). A number of steps are taken to produce the map in GIS. First, a susceptibility map is created by considering passive or conditioning factors, which depend on the nature, structure and morphology of the ground. Second, a hazard map is created by considering active or trigger factors, which cause instabilities within hillsides and determine the magnitude and speed of their movements. Finally, the ground movements risk map is obtained by combining the susceptibility and hazard maps with risk and vulnerability map (degree of potential damage) and risk exposure map (estimate of damage, human casualty and economic loss). The resulting ground movements risk map shows very high risk at the foot of escarpments and abrupt reliefs where urban areas, fractures and/or roads are present. High risk prevails in the geomorphologic domains of fluvial incisions, where the slopes are high, as well as in areas with escarped hillsides. Medium-risk areas are distributed around the marked reliefs, forming zones of filling and slightly flat surfaces. Low-risk areas appear in topographically flat areas, since they are domains of terraces, pediments or degraded surfaces. Very scattered and less-extended areas present very low risk. [ABSTRACT FROM AUTHOR]

Recreational boating is a leisure and sports activity that has aroused growing interest among users, tourists, and the general public. However, in the last decade, a problem has arisen concerning the abandonment of recreational boats. It is a problem that has become even more acute in times of economic recession. It is, therefore, necessary to find an urgent solution in order to reduce potential environmental risks. This work aims to analyze the state of the question through bibliometrics to know which topics are trending and contrast these findings with a Delphi analysis. The main results focus on the need for greater agility in the court adjudication process and the need for a specific legal framework for the scrapping of recreational craft. In conclusion, it is vital to integrate the circular economy into shipbuilding and scrapping processes to ensure the sustainability of the sector and the environment. [Display omitted] • Ship abandonment is an economic and social problem that affects the environment. • Circular Economy must be integrated into processes for the industry's sustainability. • Vessel condition and bureaucracy are critical factors for extending their life cycle. • Ship abandonment not only affects Spain, but is a problem in many countries. [ABSTRACT FROM AUTHOR]

Studies regarding how environmental risk evolves in abandoned mining areas in the medium term have been seldom carried out. The answer to this question is not obvious despite it is essential in order to evaluate the need to take urgent control measures in these areas. Fifty-two samples corresponding to soils (from natural pasture and arable lands) and mine tailings were collected in the surroundings of an old Spanish Pb/Zn mine (San Quintín, Central Spain). Current concentrations of pseudo-total and available metal (loid)s (Pb, Zn, Cd, Cu, As and Ag) were determined and the environmental risk assessment (ERA) was conducted with these data and those corresponding to a sampling previously carried out in 2006. ERA was carried out by calculating the geoaccumulation index (Igeo), the pollution load index (PLI) and the potential ecological risk index (PER). Results demonstrated that Pb and Zn concentrations have increased in the soils of the plots surrounding the mining areas causing a moderate rise in most of the determined pollution indices between 2006 and 2020. It was especially significant in the pastureland areas, with increases up to 17% in the number of soil samples that reached the highest risk classification in 2020 as compared to those taken in 2006. The results obtained here demonstrate that the environmental risk can actually increase in a continuous way in abandoned mining areas despite the closure of the mining operation and the effect of the possible natural attenuation. [Display omitted] • Mine tailings, arable land and pastureland samples were taken and analyzed. • Environmental risk was assessed by using several pollution risk indices. • Environmental hazard was mainly due to high levels of Pb and Zn. • Metals in pastureland plots were one order of magnitude higher than background values. • Metal (loid)s dispersion really increased the environmental risk in the studied period. [ABSTRACT FROM AUTHOR]

In the building of marine brine discharge pipelines from desalination plants, there are some technical and environmental conditions that require previous numerous studies to guarantee their viability. In the project of Águilas desalination plant with a production capacity of 180.000m³/day, in Murcia, Spain, a marine emissary was designed. It was made up of various sections that entail different building complexities. The main difficulty was to build a tunnel in the rocky massif called "Peñon del Roncaor"; the tunnel was dug through a piling of 443m of length and an exterior diameter of 2.400mm that would have come up at a depth of 12m to join the submarine section of 290m of length. These more detailed geotechnical studies showed a great heterogeneity in the composition of the materials to be excavated from the Peñon. In order to avoid any risk of affecting to the castle right above considered of cultural interest, a new tracing of the tunnel was designed. The new tracing runs the Peñon's outer south borders right into the dumping area. This new tracing implies greater length of piping and greater seabed marine area occupation as well; it required carrying out additional bionomic studies to guarantee its environmental compatibility. We must bear in mind that the marine surroundings of Águilas are a protected area included in the Red Natura 2000 (LIC Submerged Costal Strip of the Murcia Region) whose predominant bionomic community is the Posidonia oceanica beds, limited to the Southwest by another less dense seagrass of Cymodocea nodosa. These seagrass meadows and rock communities suffer anthropic pressure for its proximity to the city of Águilas, as near-shore marine discharges, fishing activity, and others. And, there are other affections of natural condition: terrigenous sediments and nutrients that get to the dry riverbed name El Charco, having seriously affected the species of greater natural value and the implementation of those ubiquitous species, and thus impoverishing habitat in general. Due to the fact that P. oceanica seagrasses have very low tolerance to increased salinity in the western Mediterranean Sea; a hydrodynamic model was developed to estimate the likely dilution of the brine discharge for this new solution. Other works comprise a bathymetric survey to establish the profile of the ocean bottom--very important for pipeline construction--a sediment characterization, the study of the oceanographic conditions and a monitoring study of the marine water quality to settle the values of the water quality in the preoperation moment and the parameters needed for process designing. During the construction of the pipeline, an environmental surveillance program was developed. And at the end of the stage, a study was developed to know the impacts produced by the works carried out and to establish the "zero situation" before start of the operation phase. In addition to that, a very strict environmental legislation was applied along the process. These regulations included exhaustive and systematic controls of several environmental parameters when starting and during the plant operation. [ABSTRACT FROM AUTHOR]

Abstract: There have been no previous risk assessment studies on citrus pesticides in Spain. The aim of this work was to estimate the risks caused by worst-case drift scenarios of the principal pesticides used on the crop, assessing possible damage to the environment and human health. A field survey was carried out, characterizing the specific conditions of plant protection product applications to citrus crops in Spain. Six targets were identified as being the most affected by droplet spray drift in Spain, and more broadly in most Mediterranean conditions: aquatic organisms, earthworms, bees, adult bystanders, child bystanders and residents. Three drift estimation models were used to assess the amount of drift at specific distances downwind of a field in order to calculate Risk Indicators. These showed safe conditions for earthworms and residents, but also indicated that some pesticides may pose a risk to aquatic organisms, even with a 20 m buffer zone, and also to bees, and adult and child bystanders. In general, results generated similar consequences of hazard risk independent of the drift prediction model used, indicating that toxicological data are more relevant for predicting risks. [Copyright &y& Elsevier]

Abstract: The city of Huelva and surrounding areas are affected by several sources of pollution such as acid mine drainage, industrial complexes, urban wastes and agriculture activities that could pose an important environmental risk. For this reason, the modified BCR (three steps) sequential extraction method was applied to evaluate the mobility and bioavailability of the trace elements in 25 representative samples of the study area. The operational scheme of the BCR was classified into three steps: water/acid soluble fraction, reducible and oxidisable fraction. The mobility sequence based on the sum of three first phases was: Cu (82.01%)>Zn (71.14%)>Cd (68.35%)>Ni (50.44%)>Pb (36.39%)>Cr (29.22%)>As (18.82%). Among metals, Cd poses a serious threat to human health and the environment due to the calculated high percentage of mobility. Additionally, multivariate statistical techniques (principal components and cluster analyses) were applied to the chemical results to evaluate the degree of metallic pollution and the levels of association between the variables (metal-metalloids) at the different steps of sequential extraction and to recognise possible sources of potential contamination. The PCA suggests that the study area is influenced by four sources of anthropogenic contributions: acid mine drainage, industrial activities, traffic, and agriculture, aside from the natural sources characteristic of the zone. Calculated environmental risk index reveal a considerable-high ecological risk in the saltmarshes of the Huelva estuary probably related to acid mine drainage and the industrial complexes located in these areas, while in the north sector of Huelva the metallic content is more closer to the natural sources values. The results obtained suggest the need for corrective remediation measures due to the higher accumulation of potentially dangerous metals, which in most cases exceed the limits established by certain legislation. [Copyright &y& Elsevier]

Abstract: In this work, the degradation of anionic and non-ionic surfactants in agricultural soil amended with sewage sludge is reported. The compounds analysed were: linear alkylbenzene sulphonates (LAS) with a 10–13 carbon alkylic chain, and nonylphenolic compounds (NPE), including nonylphenol (NP) and nonylphenol ethoxylates with one and two ethoxy groups (NP1EO and NP2EO). The degradation studies were carried out under winter (12.7°C) and summer (22.4°C) conditions in Andalusia region. The concentration of LAS was reduced to 2% of the initial concentration 100day after sludge-application to the soil. The half-life time measured for LAS homologues were ranged between 4 and 14days at 12.7°C and between 4 and 7days at 22.4°C. With regard to NPE compounds, after 8 and 4days from the beginning of the experiment at 12.7 and 22.4°C, respectively, their concentration levels were increased to 6.5 and 13.5mg/kgdm (dry matter) as consequence of the degradation of nonylphenol polyethoxylates. These concentration levels were reduced to 5% after 63 and 70days for 12.7°C and 22.4°C, respectively. The half-life times measured for NPEs were from 8 to 16days at 12.7°C and from 8 to 18days at 22.4°C. Environmental risk assessment revealed that for LAS homologues no environment risk could be expected after 7 and 8days of sludge application to the soil for 22.4 and 12.7°C, respectively; however, potential toxic effects could be observed for the nonylphenolic compounds during the first 56days after sludge application to the soil. [Copyright &y& Elsevier]

Abstract: Metal contamination from acid mine drainage (AMD) is a serious problem in the southwest of the Iberian Peninsula, where the Iberian Pyrite Belt is located. This zone contains original sulfide reserves of about 1700Mt distributed among more than 50 massive sulfide deposits. Weathering of these minerals releases to the waters significant quantities of toxic elements, which severely affect the sediments and surface waters of the region. The main goal of this paper is to evaluate the toxicity and the potential risk associated with the mining areas using Microtox test and different factors which assess the degree of contamination of the sediments and waters. For this, a natural stream polluted by AMD-discharge from an abandoned mine has been studied. The results show that elevated concentrations of Cu, As and Zn involve an important potential risk on the aquatic environment, associated both with sediments and waters. Microtox test informs that the sediments are extremely or very toxic, mainly related to concentrations of Fe, As, Cr, Al, Cd, Cu and Zn. Pollution is mainly transferred to the sediments increasing their potential toxicity. A natural creek affected by AMD can store a huge amount of pollution in its sediments while exhibiting a not very low water pH and low water metal concentration. [Copyright &y& Elsevier]

Pharmaceutical and personal care products (PPCPs) can be incorporated into ecosystems and pose potential environmental and health hazards. These pollutants are becoming omnipresent in the environment because they are introduced by several sources, being particularly important the contribution of human-derived pharmaceuticals. The presence of PPCPs in waters has received increasing attention in recent years, resulting in great concern regarding their occurrence, transformation, fate and environmental risk. For that reason, the pharmaceuticals carbamazepine (CBZ), diclofenac (DIC), ibuprofen (IBU), ketoprofen (KET) and naproxen (NPX) were measured in the waters and sludge of several parts of a double step activated sludge wastewater treatment plant (WWTP) from Murcia (Spain). With these results, the biological degradation constant, the sorption coefficient and the pharmaceutical removal were calculated. Possible risks to humans and ecosystems were also evaluated. These showed good degradation of IBU and NPX (74.4 and 84.9%, respectively), while CBZ didn't display any degradation. DIC was the compound most likely to be sorbed into the sludge (3.09 L kg−1). The PPCPs removal in this double stage WWTP was compared to a previous data obtained in a WWTP of the same region with an activated sludge (single biological batch reactor). The results showed a decrease in the removal of the double stage plant, probably due to the lower hydraulic retention time employed. The study of the human and ecological risk quotients indicates a low risk of the selected pharmaceuticals (RQ < 0.1). • The pharmaceutical removal was higher than 70% for ibuprofen and naproxen. • The pharmaceutical biodegradation was negative for carbamazepine. • The highest sludge/water partitioning coefficient was obtained for diclofenac.. • Low Risk Quotients were observed for the selected pharmaceuticals. [ABSTRACT FROM AUTHOR]

• Seasonal variation of pharmaceuticals present in a Spanish river was monitored. • Use of different MS instruments permitted comprehensive monitoring. • Four out of five antibiotics included in the EU Watch List were found. • Ecological risks were mainly driven by phenazone > azithromycin > diclofenac. • Severe ecological risks observed in 3 out of 19 sampling sites downstream of WWTPs. Pharmaceuticals are biologically active molecules that may exert toxic effects to a wide range of aquatic organisms. They are considered contaminants of emerging concern due to their common presence in wastewaters and in the receiving surface waters, and the lack of specific regulations to monitor their environmental occurrence and risks. In this work, the environmental exposure and risks of pharmaceuticals have been studied in the Mijares River, Eastern Mediterranean coast (Spain). A total of 57 surface water samples from 19 sampling points were collected in three monitoring campaigns between June 2018 and February 2019. A list of 40 compounds was investigated using a quantitative target UHPLC-MS/MS method. In order to complement the data obtained, a wide-scope screening of pharmaceuticals and metabolites was also performed by UHPLC-HRMS. The ecological risks posed by the pharmaceutical mixtures were evaluated using species sensitivity distributions built with chronic toxicity data for aquatic organisms. In this study, up to 69 pharmaceuticals and 9 metabolites were identified, out of which 35 compounds were assessed using the quantitative method. The highest concentrations in water corresponded to acetaminophen, gabapentin, venlafaxine, valsartan, ciprofloxacin and diclofenac. The compounds that were found to exert the highest toxic pressure on the aquatic ecosystems were principally analgesic/anti-inflammatory drugs and antibiotics. These were: phenazone > azithromycin > diclofenac, and to a lower extent norfloxacin > ciprofloxacin > clarithromycin. The monitored pharmaceutical mixtures are expected to exert severe ecological risks in areas downstream of WWTP discharges, with the percentage of aquatic species affected ranging between 65% and 82% in 3 out of the 19 evaluated sites. In addition, five antibiotics were found to exceed antibiotic resistance thresholds, thus potentially contributing to resistance gene enrichment in environmental bacteria. This work illustrates the wide use and impact of pharmaceuticals in the area under study, and the vulnerability of surface waters if only conventional wastewater treatments are applied. Several compounds included in this study should be incorporated in future water monitoring programs to help in the development of future regulations, due to their potential risk to the aquatic environment. [ABSTRACT FROM AUTHOR]

Samples from 13 beaches along the northern Spanish coast, a region with a history of heavy industries, were first screened to identify signs of pollution. High concentrations of Hg and Ba on Vega beach were found, both elements belong to the fluorite ore paragenesis, mined in the surroundings. Samples of beach and fluvial sediments, and nearby soils were collected in Vega beach area to address potential Hg pollution, fate and sources. Most samples showed a similar pollutants fingerprint to that of beach samples, especially those taken from white dunes, registering notable Hg concentrations. Hg was enriched in the finer fractions, and overall the main input was attributed to the mining waste discharged along the coast in the past. Although a specific risk assessment and study of the submerged sediments are advisable for this area, Hg bioavailability and methylation were low, thus indicating that this metal poses a reduced environmental risk. • Pollution by PTEs in several beaches from Northern Spain was assessed. • Comprehensive study in Vega beach was performed due to high concentrations of Hg. • Dunes of the beach and surrounding soils presented the major affection. • Multivariate statistics linked pollution to fluorite paragenesis and its mining. [ABSTRACT FROM AUTHOR]

A significant proportion of scientific studies consider pregnant and breastfeeding women as vulnerable subjects. The objective of this study was to analyse the perception of pregnant and breastfeeding women regarding their participation in environmental research studies. Our work is a descriptive and interpretative observational study that has been developed under the qualitative research paradigm following a phenomenological and ethnographic perspective. The study involved 173 women selected intentionally in two Spanish autonomous communities. To obtain the primary data, we relied upon 111 interviews, four focused ethnographies and eight focus groups. The data encoding and analysis was carried out with the help of NVivo 12 software (QSR International, Boston, MA, USA). We evidenced the need of pregnant and breastfeeding women for more detailed and accurate information on the risk of environmental pollutant exposure during their crucial life stage. In addition, these women claimed for a more participatory role in research studies. Pregnant and breastfeeding women in Spain ask for greater interaction with researchers and propose a dialogical relationship between valid partners. We conclude that our pregnant and breastfeeding women claim more research focused on their collective, as well as clearer, more accessible and structured information on the risks of exposure to environmental contaminants. In addition, they do not want to simply be informants; rather, they ask to be active and empowered members by providing their opinions and arguments throughout the research process.

Pyriproxyfen (PPF) is a synthetic substance and an insect juvenile hormone agonist with growth regulating effect. It is used worldwide as a pesticide in agriculture and public health campaigns, including the control of Aedes aegypti proliferation. It has low volatility, high Kow value and high lability in aerobic aquatic systems but is considered persistent in anaerobic systems, with a half-life of 288.9 days. The objective of this study is to survey the environmental contamination by pyriproxyfen in aquatic environmental matrices, to review the acute and chronic toxicity in non-target aquatic organisms and to make a risk assessment for the organisms addressed in the bibliographic survey. Pyriproxyfen quantification studies in aquatic environmental matrices are quite scarce and punctual-not representative of regional and global contamination. The water of the River Júcar (Spain) presented the highest concentration of PPF (99.59 ng L -1 ) among the matrices analysed, which is equivalent to 1% of the maximum dose allowed by the World Health Organization for use in drinking water. Acute and chronic aquatic toxicity studies with LC50, EC50, LOEC and NOEC values of PPF were compiled and interpreted to evaluate possible risks to non-target aquatic organisms. Pyriproxyfen caused a high risk at concentrations detected in aquatic environments for Daphnia magna, with probable reproductive effects and occasional survival risk. This species was the most sensitive to the pesticide, with the lowest estimated concentration of 50 % of effect values, followed by a freshwater fish (Xiphophorus maculatus) and estuarine crustaceans (Eurytemora affinis and Leander tenuicornis). The most resistant organisms to PPF within the endpoints addressed in this review were Danio rerio (zebrafish) and Capitella sp. (polychaete). Through the species sensitivity distribution (SSD), it was possible to estimate HC5 at 0.214 μg L -1 and that 2.3 % of the species present high sensitivity to pyriproxyfen in the environmental concentration detected in river water and 25.82 % of the species are affected in the concentration allowed for lavicidal use. In order to obtain more accurate risk estimates, we suggest ecotoxicological assessments in other species, covering various taxa, with emphasis on microcrustaceans due to their fundamental role in the aquatic food web and taxonomic proximity to pesticide target organisms. Furthermore, additional studies of contamination in aquatic environmental matrices are required, with particular attention to freshwater and estuarine environments due to the proximity to the sources of pyriproxyfen and environmental characteristics suggesting high accumulation. Thus, it will be possible to estimate realistic exposure levels and risks in different environments, contributing to effective and safe decision making, integrating development, public health and environmental policy., Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Mediterranean basins are exposed to overexploitation and high pollution level, which produce degradation of water systems and a loss of biodiversity. To ensure a good ecological state of rivers, we proposed to develop a water quality model to simulate and evaluate environmental risk at a large scale.The main objective of this study is to model the water quality of altered water regime of each type of water river bodies and analyse three physicochemical parameters (Total Organic Carbon [TOC], Phosphates and Ammonium). The methodology was applied to the Catalonia Internal Basins [CIC by its Spanish acronym], in the North-west of Spain. The Rapid Environmental Status tool [R2EA by its Spanish acronym] was used to include the most important elements that affect the natural regime of the river and the main sources of pollution. This tool forms part of the Decision Support System [DSS] shell AQUATOOL (Andreu, Capilla, & Sanchís, 1996). Once the model was developed, it was calibrated using the records of the observed data provided by the Water Catalan Agency [ACA by its Spanish acronym].Finally, we compared the actual ecological status with the classification did with the concentration series generated with the R2EA model. The model correctly represents the environmental state of more than 80% of the water bodies, based on TOC and Phosphates results. The ammonium is the parameter worst represented with a success rate of 70% respect the observed data. In addition, the results showed a high environmental risk during summer months and droughts. Many studies about droughts are expected to increment in frequency, intensity and magnitude of this climatic phenomenon and a general reduction of inflows of the semi-arid basins. These periods are especially critical to the aquatic ecosystems, the decrease in ecological status by increased chemical risk can be an important problem to the biologic community of these habitats.Hence, we conclude that the presented tool will be useful to the process of making decisions to manage with sustainable criteria. Besides, R2EA allows modelled water bodies without observed data control, that can be an opportunity to have an idea of the environmental status of these rivers and include or not their control in future data collections programs.Finally, the authors thank the Spanish Research Agency (MINECO) for the financial support to ERAS project (CTM2016-77804-P, including EU-FEDER funds). [ABSTRACT FROM AUTHOR]

This work analyses the presence of twenty-five pharmaceutical compounds belonging to seven different therapeutic groups and one iodinated contrast media (ICM) in a Spanish medium-size hospital located in the Valencia Region. Analysis of the target compounds in the hospital wastewater was performed by means of solid phase extraction (SPE) followed by liquid chromatography-tandem mass spectrometry analysis (HPLC-MS/MS). A screening level risk assessment combining the measured environmental concentrations (MECs) with dose-response data based on Predicted No Effect Concentration (PNEC) was also applied to estimate Hazard Quotients (HQs) for the compounds investigated. Additionally, the environmental hazard associated to the various compounds measured was assessed through the calculation of the Persistence, Bioaccumulation and Toxicity (PBT) Index, which categorizes compounds according to their environmentally damaging characteristics. The results of the study showed the presence of twenty-four out of the twenty-six compounds analysed at individual concentrations ranging from 5 ng L(-1) to 2 mg L(-1). The highest concentrations corresponded to the ICM iomeprol, found at levels between 424 and 2093 μg L(-1), the analgesic acetaminophen (15-44 μg L(-1)), the diuretic (DIU) furosemide (6-15 μg L(-1)), and the antibiotics (ABIs) ofloxacin and trimethoprim (2-5 μg L(-1)). The lowest levels corresponded to the anti-inflammatory propyphenazone, found at concentrations between 5 and 44 ng L(-1). Differences in terms of concentrations of the analysed compounds have been observed in all the therapeutic groups when comparing the results obtained in this and other recent studies carried out in hospitals with different characteristics from different geographical areas and in different seasons. The screening level risk assessment performed in raw water from the hospital effluent showed that the analgesics and anti-inflammatories (AAFs) acetaminophen, diclofenac, ibuprofen and naproxen, the antibiotics (ABIs) clarithromycin, ofloxacin and trimethoprim, and the β-blocker (BBL) propranolol were present at concentrations leading to HQ values higher than 10, thus indicating high risk. When applying a factor to take into account potential dilution and degradation processes, only the compound ibuprofen showed a HQ higher than 1. Likewise, the cumulative HQ or Toxic Units (TUs) calculated in the raw water for each of the therapeutic groups studied showed that these three classes of drugs were at concentrations high enough to potentially generate high risk to aquatic organisms while taking into account possible dilution and degradation processes only one of them, the AAFs can be considered to represent high risk. Finally, the environmental hazard assessment performed showed that the AAFs diclofenac and ibuprofen and the ABI clarithromycin have the highest, maximum value of 9 of PBT Index due to their inherent environmentally damaging characteristics of persistence, bioaccumulation and toxicity. The methodology followed in the present case study can be taken as a novel approach to classify and categorize pharmaceuticals on the basis of their occurrence in hospital effluents, their derived environmental risks, and their associated environmental hazard. This classification becomes important because it can be used as a model or orientation for hospitals in the process of developing environmentally sustainable policies and as an argument to justify the adoption of advanced, specific treatments for hospital effluents before being discharged into the public sewage system., (Copyright © 2015 Elsevier Inc. All rights reserved.)

The seasonal variations in the occurrence and distribution of pharmaceuticals were evaluated in seawater and sediment of Mar Menor lagoon from spring 2010 to winter 2011. A total of 20 pharmaceuticals in seawater and 14 in sediments were found at concentrations from low ngL(-)(1) up to 168ngL(-)(1) (azithromycin) in seawater and from low ngg(-1) up to 50.3ngg(-1) (xylazine) in sediments. Azithromycin, xylazine and metoprolol were the most ubiquitous compounds in seawater since they were found in all seawater samples collected. Seven compounds were quantified in both matrices: clarithromycin, erythromycin, hydrochlorothiazide, irbesartan, losartan, salicylic acid and valsartan. Seasonal distribution profiles revealed different sources of pollutants associated to both, El Albujón watercourse (which receives the input of a WWTP) and other non-controlled discharges, into the lagoon. In summer the highest concentrations in seawater for most of the pharmaceuticals were detected close to main touristic nuclei, probably as consequence of sources such as the excretion from bathers and/or other non-controlled discharges, these being significantly higher than in autumn and winter for antibiotics. On the contrary, the mean concentration of lorazepam was significantly higher in colder seasons than in warmer ones. Sulfamethoxazole, erythromycin and especially clarithromycin showed hazard quotients higher than 1 in seawater at some areas of this lagoon indicating a potential risk to aquatic organisms in such specific areas., (Copyright © 2015 Elsevier Inc. All rights reserved.)

This work analyzes the seasonal variation (winter and summer) of ten drugs of abuse, six metabolites and three benzodiazepines in surface waters from the Jarama and Manzanares Rivers in the Madrid Region, the most densely populated area in Spain. The occurrence of these compounds in tap water in this region is also investigated and a preliminary human health risk characterization performed for those substances found in tap water. Finally, a screening level risk assessment that combines the measured environmental concentrations (MECs) with dose-response data to estimate Hazard Quotients (HQs) for the compounds studied is also presented. The results of this study show the presence of fourteen out of the nineteen compounds analyzed in winter and twelve of them in summer. The most ubiquitous compounds, with a frequency of detection of 100% in both seasons, were the cocaine metabolite benzoylecgonine (BE), the amphetamine-type stimulant (ATS) ephedrine (EPH), the opioid methadone (METH), the METH metabolite 2-ethylene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and the three benzodiazepines investigated, namely alprazolam (ALP), diazepam (DIA) and lorazepam (LOR). The highest concentrations observed corresponded to EPH (1020ngL(-1) in winter and 250ngL(-1) in summer). The only compounds not detected in both seasons were heroin (HER) and its metabolite 6-acetylmorphine (6ACM), lysergic acid diethylamide (LSD) and its metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD), and Δ(9)-tetrahydrocannabinol (THC). In terms of overall concentration, all sampling points presented higher concentrations in winter than in summer. Statistical analyses performed to gather evidence concerning occasional seasonal differences in the concentrations of individual substances between summer and winter showed statistically significantly higher concentrations (p<0.05) of BE, EPH and the opioid morphine (MOR) in winter than in summer. Two out of the nineteen compounds studied, namely cocaine (CO) and EPH, were detected in tap water from one sampling point at concentrations of 1.61 and 0.29ngL(-1), respectively. The preliminary human health risk characterization showed that no toxic effects could be expected at the detected concentration level in tap water. The screening level risk assessment showed that MOR, EDDP and the THC metabolite 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THC-COOH) were present in at least one of the sampling sites in a concentration leading to a Hazard Quotient (HQ) value between 1.0 and 10.0, thus indicating some possible adverse effects. The cumulative HQ or Toxic units (TUs) calculated for each of the groups studied showed that opioids and cannabinoids were present at concentrations high enough to potentially generate some adverse effects on at least one sampling point., (Copyright © 2014 Elsevier Ltd. All rights reserved.)